Details of the Target

General Information of Target

Target ID LDTP00261
Target Name Dynactin subunit 6 (DCTN6)
Gene Name DCTN6
Gene ID 10671
Synonyms
WS3; Dynactin subunit 6; Dynactin subunit p27; Protein WS-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQA
LIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILT
SGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKT
MKGSSTPVKN
Target Bioclass
Other
Family
Dynactin subunits 5/6 family, Dynactin subunit 6 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Uniprot ID
O00399
Ensemble ID
ENST00000221114.8
HGNC ID
HGNC:16964

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K38(8.33)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C18(3.62)  LDD3312  [3]
BTD
 Probe Info  		C18(0.86)  LDD2107  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
W1
 Probe Info  		N.A.  LDD0236  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C18(1.08)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C18(1.04)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C18(1.18); C148(0.93)  LDD1509  [8]
 LDCM0259  AC14 HEK-293T C18(1.07)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C18(1.26); C148(1.17)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C18(1.07)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C18(1.10)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C18(0.88); C148(0.83)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C18(1.19)  LDD1518  [8]
 LDCM0281  AC21 HEK-293T C18(1.35)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C18(1.22)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C18(1.30); C148(0.78)  LDD1522  [8]
 LDCM0285  AC25 HEK-293T C18(1.05)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C18(0.95)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C18(0.93); C148(0.88)  LDD1526  [8]
 LDCM0289  AC29 HEK-293T C18(1.21)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C18(0.98); C148(0.93)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C18(1.14)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C18(1.09); C148(0.88)  LDD1531  [8]
 LDCM0294  AC33 HEK-293T C18(1.16)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C18(1.20)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C18(1.23); C148(1.13)  LDD1535  [8]
 LDCM0298  AC37 HEK-293T C18(1.20)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C18(1.38)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C18(1.31); C148(0.97)  LDD1539  [8]
 LDCM0303  AC41 HEK-293T C18(1.23)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C18(1.04)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C18(1.27); C148(0.99)  LDD1544  [8]
 LDCM0307  AC45 HEK-293T C18(1.18)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C18(1.08)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C18(1.12); C148(0.94)  LDD1548  [8]
 LDCM0311  AC49 HEK-293T C18(1.11)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C18(1.03)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C18(1.23)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C18(0.97); C148(0.92)  LDD1553  [8]
 LDCM0316  AC53 HEK-293T C18(1.36)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C18(1.33)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C18(1.30); C148(1.05)  LDD1557  [8]
 LDCM0320  AC57 HEK-293T C18(1.29)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C18(1.07)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C18(1.06); C148(0.93)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C18(1.05)  LDD1562  [8]
 LDCM0325  AC61 HEK-293T C18(1.14)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C18(1.18)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C18(1.19); C148(0.93)  LDD1566  [8]
 LDCM0334  AC7 HEK-293T C18(1.03); C148(1.02)  LDD1568  [8]
 LDCM0248  AKOS034007472 HEK-293T C18(1.20)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C18(1.27)  LDD1570  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C18(1.74)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C18(1.12)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C18(0.89)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C18(1.06); C148(1.09)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C18(1.03)  LDD1574  [8]
 LDCM0372  CL103 HEK-293T C18(1.02)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C18(1.00); C148(1.13)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C18(1.19)  LDD1578  [8]
 LDCM0376  CL107 HEK-293T C18(1.18)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C18(1.00); C148(0.79)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C18(1.11)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C18(1.01); C148(1.01)  LDD1583  [8]
 LDCM0381  CL111 HEK-293T C18(1.02)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C18(1.12); C148(0.86)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C18(1.42)  LDD1587  [8]
 LDCM0385  CL115 HEK-293T C18(1.08)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C18(1.18); C148(1.16)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C18(1.25)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C18(1.04)  LDD1593  [8]
 LDCM0391  CL120 HEK-293T C18(1.13); C148(1.38)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C18(1.20)  LDD1596  [8]
 LDCM0394  CL123 HEK-293T C18(0.99)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C18(1.12); C148(1.05)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C18(1.17)  LDD1600  [8]
 LDCM0398  CL127 HEK-293T C18(1.13)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C18(1.21); C148(0.91)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C18(1.09)  LDD1604  [8]
 LDCM0402  CL15 HEK-293T C18(1.08)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C18(0.97); C148(1.00)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C18(0.93)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C18(1.03)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C18(1.03); C148(1.09)  LDD1610  [8]
 LDCM0409  CL21 HEK-293T C18(0.93)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C18(0.93)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C18(1.15); C148(1.18)  LDD1615  [8]
 LDCM0413  CL25 HEK-293T C18(1.28)  LDD1617  [8]
 LDCM0415  CL27 HEK-293T C18(1.13)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C18(1.02); C148(1.08)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C18(0.98)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C18(0.95)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C18(1.14)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C18(1.20); C148(0.91)  LDD1624  [8]
 LDCM0422  CL33 HEK-293T C18(0.92)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C18(1.00)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C18(1.04); C148(1.00)  LDD1628  [8]
 LDCM0426  CL37 HEK-293T C18(1.22)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C18(1.14)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C18(0.93); C148(0.87)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C18(1.10); C148(1.03)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C18(1.05)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C18(1.18)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C18(0.98); C148(1.14)  LDD1637  [8]
 LDCM0435  CL45 HEK-293T C18(1.05)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C18(1.00)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C18(1.18); C148(1.00)  LDD1641  [8]
 LDCM0439  CL49 HEK-293T C18(1.23)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C18(1.11)  LDD1644  [8]
 LDCM0443  CL52 HEK-293T C18(1.07); C148(1.11)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C18(1.08)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C18(1.03)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C18(0.96); C148(1.11)  LDD1649  [8]
 LDCM0448  CL57 HEK-293T C18(0.92)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C18(1.06)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C18(1.20); C148(1.00)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C18(0.83)  LDD1654  [8]
 LDCM0453  CL61 HEK-293T C18(1.17)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C18(1.16)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C18(1.00); C148(1.05)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C18(1.25)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C18(1.17)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C18(1.00); C148(1.16)  LDD1662  [8]
 LDCM0461  CL69 HEK-293T C18(1.05)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C18(0.90); C148(1.21)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C18(1.23)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C18(1.10); C148(1.05)  LDD1667  [8]
 LDCM0466  CL73 HEK-293T C18(0.95)  LDD1669  [8]
 LDCM0469  CL76 HEK-293T C18(0.99); C148(0.92)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C18(0.99)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C18(1.03)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C18(1.06); C148(1.17)  LDD1675  [8]
 LDCM0475  CL81 HEK-293T C18(1.11)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C18(1.01)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C18(1.05); C148(1.28)  LDD1680  [8]
 LDCM0479  CL85 HEK-293T C18(1.37)  LDD1682  [8]
 LDCM0481  CL87 HEK-293T C18(1.06)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C18(1.11); C148(0.88)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C18(1.11)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C18(0.92)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C18(0.93)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C18(1.07); C148(0.92)  LDD1689  [8]
 LDCM0488  CL93 HEK-293T C18(1.06)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C18(1.25)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C18(1.00); C148(0.71)  LDD1693  [8]
 LDCM0492  CL97 HEK-293T C18(1.07)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C18(0.90)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C18(1.08)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C18(1.98)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C18(1.04)  LDD1671  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C18(1.06)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C18(1.10)  LDD1497  [8]
 LDCM0024  KB05 HMCB C18(3.62)  LDD3312  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C18(0.86)  LDD2107  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C18(0.67)  LDD2150  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402