Details of the Target

General Information of Target

Target ID LDTP00087
Target Name Paralemmin-3 (PALM3)
Gene Name PALM3
Gene ID 342979
Synonyms
Paralemmin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE
PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGH
RPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDS
SEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPEL
EAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQ
TSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEG
LEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMS
PVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEE
EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNL
EQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQG
PLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEAS
GPKQKTCQCCAVM
Target Bioclass
Other
Family
Paralemmin family
Subcellular location
Cytoplasm
Function ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.
Uniprot ID
A6NDB9
Ensemble ID
ENST00000340790.9
HGNC ID
HGNC:33274

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C231(1.32)  LDD3321  [1]
N1
 Probe Info  		E407(0.00); E408(0.00); S401(0.00); S406(0.00)  LDD0245  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		C231(0.00); C187(0.00)  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C231(1.05)  LDD1512  [5]
 LDCM0281  AC21 HEK-293T C231(1.47)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C231(1.05)  LDD1521  [5]
 LDCM0284  AC24 HEK-293T C231(1.11)  LDD1523  [5]
 LDCM0289  AC29 HEK-293T C231(1.33)  LDD1528  [5]
 LDCM0291  AC30 HEK-293T C231(0.96)  LDD1530  [5]
 LDCM0293  AC32 HEK-293T C231(1.12)  LDD1532  [5]
 LDCM0298  AC37 HEK-293T C231(2.10)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C231(1.10)  LDD1538  [5]
 LDCM0302  AC40 HEK-293T C231(1.16)  LDD1541  [5]
 LDCM0307  AC45 HEK-293T C231(1.17)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C231(0.98)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C231(1.08)  LDD1549  [5]
 LDCM0312  AC5 HEK-293T C231(1.28)  LDD1551  [5]
 LDCM0316  AC53 HEK-293T C231(1.36)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C231(1.06)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C231(1.15)  LDD1558  [5]
 LDCM0323  AC6 HEK-293T C231(0.95)  LDD1562  [5]
 LDCM0325  AC61 HEK-293T C231(1.45)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C231(1.13)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C231(1.20)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C231(1.12)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C231(1.05)  LDD1511  [5]
 LDCM0275  AKOS034007705 HEK-293T C231(1.24)  LDD1514  [5]
 LDCM0632  CL-Sc Hep-G2 C231(20.00)  LDD2227  [4]
 LDCM0368  CL10 HEK-293T C231(0.97)  LDD1572  [5]
 LDCM0390  CL12 HEK-293T C231(1.30)  LDD1594  [5]
 LDCM0409  CL21 HEK-293T C231(1.19)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C231(1.09)  LDD1614  [5]
 LDCM0412  CL24 HEK-293T C231(1.16)  LDD1616  [5]
 LDCM0422  CL33 HEK-293T C231(1.12)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C231(1.16)  LDD1627  [5]
 LDCM0425  CL36 HEK-293T C231(1.38)  LDD1629  [5]
 LDCM0435  CL45 HEK-293T C231(1.45)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C231(1.06)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C231(1.21)  LDD1642  [5]
 LDCM0448  CL57 HEK-293T C231(3.09)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C231(1.00)  LDD1652  [5]
 LDCM0452  CL60 HEK-293T C231(1.23)  LDD1655  [5]
 LDCM0461  CL69 HEK-293T C231(1.58)  LDD1664  [5]
 LDCM0463  CL70 HEK-293T C231(1.02)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C231(1.39)  LDD1668  [5]
 LDCM0475  CL81 HEK-293T C231(1.29)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C231(1.04)  LDD1679  [5]
 LDCM0478  CL84 HEK-293T C231(1.13)  LDD1681  [5]
 LDCM0484  CL9 HEK-293T C231(1.65)  LDD1687  [5]
 LDCM0488  CL93 HEK-293T C231(1.28)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C231(1.09)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C231(1.08)  LDD1694  [5]
 LDCM0022  KB02 HEK-293T C231(0.85)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C231(1.01)  LDD1497  [5]
 LDCM0024  KB05 SH4 C231(1.32)  LDD3321  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Single Ig IL-1-related receptor (SIGIRR) Interleukin-1 receptor family Q6IA17

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402