Details of the Target

General Information of Target

Target ID LDTP00055
Target Name Transmembrane protein 131-like (TMEM131L)
Gene Name TMEM131L
Gene ID 23240
Synonyms
KIAA0922; Transmembrane protein 131-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGEL
LLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSR
DSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVL
SYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNK
VCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDS
AVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSG
IIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSV
VLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAI
FAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELAN
KLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALR
SRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEA
CPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEG
FGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPIT
VSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLE
FRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEF
MKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRI
QNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDI
CTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQ
TCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGN
NQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQE
KREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCI
QESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRG
SWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLP
QYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVH
NSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWN
TPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTH
MENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV
Target Bioclass
Other
Family
TMEM131 family
Subcellular location
Cytoplasm; Endoplasmic reticulum; Cell membrane
Function [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
Uniprot ID
A2VDJ0
Ensemble ID
ENST00000409663.7
HGNC ID
HGNC:29146

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1241(38.74)  LDD0209  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
IPM
 Probe Info  		C980(0.00); C1241(0.00)  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		13.60  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C980(2.16)  LDD0372  [8]
 LDCM0226  AC11 HEK-293T C980(1.02)  LDD1509  [9]
 LDCM0278  AC19 HEK-293T C980(1.10)  LDD1517  [9]
 LDCM0284  AC24 HEK-293T C950(0.93)  LDD1523  [9]
 LDCM0287  AC27 HEK-293T C980(0.94)  LDD1526  [9]
 LDCM0290  AC3 HEK-293T C980(1.04)  LDD1529  [9]
 LDCM0293  AC32 HEK-293T C950(0.89)  LDD1532  [9]
 LDCM0296  AC35 HEK-293T C980(0.96)  LDD1535  [9]
 LDCM0302  AC40 HEK-293T C950(0.93)  LDD1541  [9]
 LDCM0305  AC43 HEK-293T C980(0.98)  LDD1544  [9]
 LDCM0310  AC48 HEK-293T C950(0.84)  LDD1549  [9]
 LDCM0314  AC51 HEK-293T C980(0.92)  LDD1553  [9]
 LDCM0319  AC56 HEK-293T C950(0.95)  LDD1558  [9]
 LDCM0322  AC59 HEK-293T C980(0.94)  LDD1561  [9]
 LDCM0328  AC64 HEK-293T C950(0.94)  LDD1567  [9]
 LDCM0345  AC8 HEK-293T C950(0.81)  LDD1569  [9]
 LDCM0275  AKOS034007705 HEK-293T C950(0.89)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C950(1.25)  LDD1571  [9]
 LDCM0370  CL101 HEK-293T C950(1.12)  LDD1574  [9]
 LDCM0374  CL105 HEK-293T C950(0.96)  LDD1578  [9]
 LDCM0378  CL109 HEK-293T C950(0.99)  LDD1582  [9]
 LDCM0383  CL113 HEK-293T C950(0.94)  LDD1587  [9]
 LDCM0387  CL117 HEK-293T C950(1.02)  LDD1591  [9]
 LDCM0390  CL12 HEK-293T C950(1.65)  LDD1594  [9]
 LDCM0392  CL121 HEK-293T C950(1.11)  LDD1596  [9]
 LDCM0396  CL125 HEK-293T C950(1.20)  LDD1600  [9]
 LDCM0400  CL13 HEK-293T C950(1.21)  LDD1604  [9]
 LDCM0406  CL19 HEK-293T C980(1.04)  LDD1610  [9]
 LDCM0412  CL24 HEK-293T C950(1.28)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C950(0.96)  LDD1617  [9]
 LDCM0420  CL31 HEK-293T C980(1.03)  LDD1624  [9]
 LDCM0425  CL36 HEK-293T C950(1.46)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C950(0.86)  LDD1630  [9]
 LDCM0433  CL43 HEK-293T C980(0.95)  LDD1637  [9]
 LDCM0438  CL48 HEK-293T C950(1.52)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C950(1.17)  LDD1643  [9]
 LDCM0446  CL55 HEK-293T C980(1.02)  LDD1649  [9]
 LDCM0452  CL60 HEK-293T C950(1.84)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C950(1.00)  LDD1656  [9]
 LDCM0459  CL67 HEK-293T C980(1.08)  LDD1662  [9]
 LDCM0462  CL7 HEK-293T C980(1.02)  LDD1665  [9]
 LDCM0465  CL72 HEK-293T C950(1.28)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C950(1.07)  LDD1669  [9]
 LDCM0472  CL79 HEK-293T C980(1.02)  LDD1675  [9]
 LDCM0478  CL84 HEK-293T C950(1.08)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C950(0.96)  LDD1682  [9]
 LDCM0486  CL91 HEK-293T C980(0.96)  LDD1689  [9]
 LDCM0491  CL96 HEK-293T C950(0.94)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C950(1.13)  LDD1695  [9]
 LDCM0022  KB02 T cell-activated C980(6.25)  LDD1704  [10]
 LDCM0023  KB03 Jurkat C1241(38.74)  LDD0209  [1]
 LDCM0024  KB05 NALM-6 C871(2.75)  LDD3339  [11]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840