Details of the Target

General Information of Target

Target ID LDTP00041
Target Name ADP-ribose glycohydrolase MACROD2 (MACROD2)
Gene Name MACROD2
Gene ID 140733
Synonyms
C20orf133; ADP-ribose glycohydrolase MACROD2; MACRO domain-containing protein 2; O-acetyl-ADP-ribose deacetylase MACROD2; EC 3.5.1.-; [Protein ADP-ribosylaspartate] hydrolase MACROD2; EC 3.2.2.-; [Protein ADP-ribosylglutamate] hydrolase MACROD2; EC 3.2.2.-
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQE
TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNL
NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSV
AFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFF
SVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCK
DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQE
DAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ
RNGTK
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.
Uniprot ID
A1Z1Q3
Ensemble ID
ENST00000217246.8
HGNC ID
HGNC:16126
ChEMBL ID
CHEMBL4295630

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDQP1 Deletion: p.S67IfsTer2 .
HS936T SNV: p.S348L .
HT115 SNV: p.S345L .
LNCaP clone FGC SNV: p.E331Ter .
MCC13 SNV: p.D301N .
MEWO SNV: p.P183L .
SKMEL2 SNV: p.E13K .
SW1271 SNV: p.L225S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C132(3.57)  LDD3493  [1]
IA-alkyne
 Probe Info  		C132(0.89)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C104(0.99)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C104(1.21)  LDD1508  [3]
 LDCM0276  AC17 HEK-293T C104(1.44)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C104(0.90)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C104(1.17)  LDD1518  [3]
 LDCM0284  AC24 HEK-293T C104(1.03)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C104(1.00)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C104(1.36)  LDD1525  [3]
 LDCM0293  AC32 HEK-293T C104(1.43)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C104(0.99)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C104(0.96)  LDD1534  [3]
 LDCM0302  AC40 HEK-293T C104(0.97)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C104(1.36)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C104(1.18)  LDD1543  [3]
 LDCM0310  AC48 HEK-293T C104(1.13)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C104(1.03)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C104(0.99)  LDD1552  [3]
 LDCM0319  AC56 HEK-293T C104(1.25)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C104(1.13)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C104(0.84)  LDD1560  [3]
 LDCM0328  AC64 HEK-293T C104(1.08)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C104(1.41)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C104(1.29)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C104(0.92)  LDD1514  [3]
 LDCM0390  CL12 HEK-293T C104(1.05)  LDD1594  [3]
 LDCM0404  CL17 HEK-293T C104(0.91)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C104(1.22)  LDD1609  [3]
 LDCM0412  CL24 HEK-293T C104(1.24)  LDD1616  [3]
 LDCM0417  CL29 HEK-293T C104(1.07)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C104(1.47)  LDD1623  [3]
 LDCM0425  CL36 HEK-293T C104(1.12)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C104(0.80)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C104(1.37)  LDD1636  [3]
 LDCM0438  CL48 HEK-293T C104(1.01)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C104(0.92)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C104(1.02)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C104(0.90)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C104(0.87)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C104(1.30)  LDD1655  [3]
 LDCM0457  CL65 HEK-293T C104(1.02)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C104(0.96)  LDD1661  [3]
 LDCM0465  CL72 HEK-293T C104(1.28)  LDD1668  [3]
 LDCM0470  CL77 HEK-293T C104(0.83)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C104(0.84)  LDD1674  [3]
 LDCM0478  CL84 HEK-293T C104(0.95)  LDD1681  [3]
 LDCM0483  CL89 HEK-293T C104(0.92)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C104(0.99)  LDD1688  [3]
 LDCM0491  CL96 HEK-293T C104(1.27)  LDD1694  [3]
 LDCM0625  F8 Ramos C132(1.94)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C132(0.91)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C132(0.15)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C132(1.21)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C132(1.02)  LDD2192  [2]
 LDCM0579  Fragment20 Ramos C132(1.70)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C132(0.94)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C132(0.52)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C132(0.68)  LDD2197  [2]
 LDCM0588  Fragment30 Ramos C132(0.90)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C132(1.15)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C132(0.61)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C132(0.04)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C132(1.59)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C132(2.42)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C132(0.90)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C132(1.45)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C132(1.74)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C132(1.56)  LDD2188  [2]
 LDCM0022  KB02 Ramos C132(0.89)  LDD2182  [2]
 LDCM0023  KB03 Ramos C132(2.27)  LDD2183  [2]
 LDCM0024  KB05 ZR-75-1 C132(3.57)  LDD3493  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402