Details of the Target

General Information of Target

Target ID LDTP19972
Target Name Transmembrane protein 185B (TMEM185B)
Gene Name TMEM185B
Gene ID 79134
Synonyms
FAM11B; Transmembrane protein 185B; Protein FAM11B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGFHFCIWIIFLLPPPCKKCLSPPTMNLRPPKSCGNVFYWVLVLNSGLLYKFCQTIKCRA
NWRPARAPRGWNEATERHQERRTQMETEMGGISTTYWHRLCTCTDRRAEKLVMDGNNCWF
HK
Target Bioclass
Other
Family
TMEM185 family
Subcellular location
Membrane
Uniprot ID
Q9H7F4
Ensemble ID
ENST00000426077.3
HGNC ID
HGNC:18896

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K324(7.14)  LDD0277  [1]
DBIA
 Probe Info  		C279(1.01)  LDD1514  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C279(1.01)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C279(0.80)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C279(1.01)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C279(0.69)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C279(0.86)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C279(0.89)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C279(1.05)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C279(1.01)  LDD1514  [2]
 LDCM0372  CL103 HEK-293T C279(1.05)  LDD1576  [2]
 LDCM0376  CL107 HEK-293T C279(0.96)  LDD1580  [2]
 LDCM0381  CL111 HEK-293T C279(1.08)  LDD1585  [2]
 LDCM0385  CL115 HEK-293T C279(1.09)  LDD1589  [2]
 LDCM0389  CL119 HEK-293T C279(1.24)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C279(1.09)  LDD1594  [2]
 LDCM0394  CL123 HEK-293T C279(1.20)  LDD1598  [2]
 LDCM0398  CL127 HEK-293T C279(1.20)  LDD1602  [2]
 LDCM0402  CL15 HEK-293T C279(1.13)  LDD1606  [2]
 LDCM0412  CL24 HEK-293T C279(1.10)  LDD1616  [2]
 LDCM0415  CL27 HEK-293T C279(0.95)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C279(1.27)  LDD1622  [2]
 LDCM0425  CL36 HEK-293T C279(1.09)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C279(0.80)  LDD1632  [2]
 LDCM0438  CL48 HEK-293T C279(1.15)  LDD1642  [2]
 LDCM0452  CL60 HEK-293T C279(1.11)  LDD1655  [2]
 LDCM0455  CL63 HEK-293T C279(0.86)  LDD1658  [2]
 LDCM0465  CL72 HEK-293T C279(1.02)  LDD1668  [2]
 LDCM0478  CL84 HEK-293T C279(0.97)  LDD1681  [2]
 LDCM0481  CL87 HEK-293T C279(0.99)  LDD1684  [2]
 LDCM0491  CL96 HEK-293T C279(0.95)  LDD1694  [2]
 LDCM0494  CL99 HEK-293T C279(1.25)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C279(1.10)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C279(0.86)  LDD1671  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402