Details of the Target

General Information of Target

Target ID LDTP19607
Target Name WD repeat-containing protein 53 (WDR53)
Gene Name WDR53
Gene ID 348793
Synonyms
WD repeat-containing protein 53
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHRARWLTPVIPALWEAEAGRSRGQEIETILANKKQSAMPWDQDPEQSTGNYSEDEQNGK
QKWREEGEAGRKREREKEEKNEKELQDEQENKRKRENEKQKQYPEKRLVSKSLMHTLWAK
FKLNRCPTIQESLSLSFEFDMTHKQISQWFCKTRKKYNKEMSKRKHKKKHMRWRSLCCQG
WSRTPALK
Target Bioclass
Other
Family
WD repeat WDR53 family
Uniprot ID
Q7Z5U6
Ensemble ID
ENST00000332629.7
HGNC ID
HGNC:28786

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.42  LDD0403  [1]
DBIA
 Probe Info  		C63(1.22)  LDD3332  [2]
IA-alkyne
 Probe Info  		C63(0.65)  LDD2183  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C63(1.42)  LDD1512  [4]
 LDCM0282  AC22 HEK-293T C63(1.02)  LDD1521  [4]
 LDCM0291  AC30 HEK-293T C63(0.99)  LDD1530  [4]
 LDCM0299  AC38 HEK-293T C63(1.19)  LDD1538  [4]
 LDCM0308  AC46 HEK-293T C63(0.96)  LDD1547  [4]
 LDCM0317  AC54 HEK-293T C63(1.04)  LDD1556  [4]
 LDCM0323  AC6 HEK-293T C63(1.19)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C63(1.26)  LDD1565  [4]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0368  CL10 HEK-293T C63(1.03)  LDD1572  [4]
 LDCM0410  CL22 HEK-293T C63(0.91)  LDD1614  [4]
 LDCM0423  CL34 HEK-293T C63(1.02)  LDD1627  [4]
 LDCM0436  CL46 HEK-293T C63(0.95)  LDD1640  [4]
 LDCM0449  CL58 HEK-293T C63(1.11)  LDD1652  [4]
 LDCM0463  CL70 HEK-293T C63(1.02)  LDD1666  [4]
 LDCM0476  CL82 HEK-293T C63(0.98)  LDD1679  [4]
 LDCM0489  CL94 HEK-293T C63(1.42)  LDD1692  [4]
 LDCM0572  Fragment10 Ramos C63(0.62)  LDD2189  [3]
 LDCM0574  Fragment12 Ramos C63(1.05)  LDD2191  [3]
 LDCM0579  Fragment20 Ramos C63(0.78)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C63(0.98)  LDD2195  [3]
 LDCM0578  Fragment27 Ramos C63(0.93)  LDD2197  [3]
 LDCM0589  Fragment31 Ramos C63(0.88)  LDD2200  [3]
 LDCM0468  Fragment33 Ramos C63(0.90)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C63(1.25)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C63(0.78)  LDD2184  [3]
 LDCM0614  Fragment56 Ramos C63(0.67)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C63(0.69)  LDD2186  [3]
 LDCM0022  KB02 8305C C63(1.21)  LDD2248  [2]
 LDCM0023  KB03 Ramos C63(0.65)  LDD2183  [3]
 LDCM0024  KB05 MKN45 C63(1.22)  LDD3332  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402