Details of the Target

General Information of Target

Target ID LDTP19498
Target Name Myb/SANT-like DNA-binding domain-containing protein 2 (MSANTD2)
Gene Name MSANTD2
Gene ID 79684
Synonyms
C11orf61; Myb/SANT-like DNA-binding domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVDSGTEARARGKAEAGLQDGISGPATARVNGKTQAEAVAEAELKTESVTQAKAGDGAMT
RTHTVTYREAMAVTREVIKVEDTTKTRVMVETKTKPLAERSIVPQTKSKAMPMSRVSTVT
KSEVKVVAVIEANIRSYAKSHDKANTGSRPDRREETSIGMKSSDEDEENICSWFWTGEEP
SVGSWFWPEEETSLQVYKPLPKIQEKPKPTHKPTLTIKQKVIAWSRARYIVLVPVEGGEQ
SLPPEGNWTLVETLIETPLGIRPLTKIPPYHGPYYQTLAEIKKQIRQREKYGPNPKACHC
KSRGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQDIIHDVGITVMIENL
VNNPNVKEHPGALSMVDDSSESSEEPKSGESYIHQVCKGIISCPLNSPVQLAGLKLLGHL
SIKFEDHYVITSYIPDFLTLLNKGSVKTKFYVLKVFSCLSKNHANTRELISAKVLSSLVA
PFNKNESKANILNIIEIFENINFQFKTKAKLFTKEKFTKSELISIFQEAKQFGQKLQDLA
EHSDPEVRDKVIRLILKL
Target Bioclass
Transcription factor
Uniprot ID
Q6P1R3
Ensemble ID
ENST00000239614.8
HGNC ID
HGNC:26266

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH358 Substitution: p.E8Q .
TOV21G SNV: p.G90W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C165(0.89)  LDD2099  [2]
DBIA
 Probe Info  		C99(10.01)  LDD0209  [3]
IPM
 Probe Info  		C99(0.00); C5(0.00)  LDD0025  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C165(0.73)  LDD2117  [2]
 LDCM0230  AC113 PaTu 8988t C99(0.51)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C99(0.43)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C99(0.59)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C99(0.64)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C99(0.53)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C99(0.87)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C99(0.47)  LDD1115  [6]
 LDCM0238  AC120 PaTu 8988t C99(0.62)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C99(0.41)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C99(0.97)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C99(1.02)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C99(0.80)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C99(1.65)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C99(1.07)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C99(0.64)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C99(0.42)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C99(0.65)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C99(0.70)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C99(0.81)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C99(1.02)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C99(0.83)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C99(0.80)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C99(0.64)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C99(0.44)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C99(0.62)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C99(0.63)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C99(0.52)  LDD1137  [6]
 LDCM0260  AC140 PaTu 8988t C99(0.64)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C99(0.84)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C99(0.67)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C99(1.10)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C99(0.85)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C99(1.17)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C99(1.48)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C99(2.00)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C99(1.35)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C99(1.42)  LDD1148  [6]
 LDCM0271  AC150 PaTu 8988t C99(1.59)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C99(2.77)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C99(1.16)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C99(1.79)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C99(1.71)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C99(1.58)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C99(1.13)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C99(1.58)  LDD2169  [6]
 LDCM0285  AC25 PaTu 8988t C99(1.03)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C99(0.92)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C99(0.87)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C99(1.18)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C99(0.86)  LDD1168  [6]
 LDCM0291  AC30 PaTu 8988t C99(0.95)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C99(1.46)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C99(0.89)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C99(2.00)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C99(1.50)  LDD1174  [6]
 LDCM0367  CL1 PaTu 8988t C99(0.84)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C99(0.98)  LDD1247  [6]
 LDCM0379  CL11 PaTu 8988t C99(0.74)  LDD1258  [6]
 LDCM0382  CL112 PaTu 8988t C99(1.46)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C99(1.12)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C99(1.69)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C99(1.15)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C99(1.70)  LDD1265  [6]
 LDCM0390  CL12 PaTu 8988t C99(0.84)  LDD1269  [6]
 LDCM0400  CL13 PaTu 8988t C99(1.52)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C99(1.90)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C99(1.17)  LDD1281  [6]
 LDCM0407  CL2 PaTu 8988t C99(1.30)  LDD1286  [6]
 LDCM0418  CL3 PaTu 8988t C99(0.85)  LDD1297  [6]
 LDCM0429  CL4 PaTu 8988t C99(0.85)  LDD1308  [6]
 LDCM0440  CL5 PaTu 8988t C99(1.28)  LDD1319  [6]
 LDCM0451  CL6 PaTu 8988t C99(1.17)  LDD1330  [6]
 LDCM0462  CL7 PaTu 8988t C99(1.21)  LDD1341  [6]
 LDCM0473  CL8 PaTu 8988t C99(1.01)  LDD1352  [6]
 LDCM0484  CL9 PaTu 8988t C99(1.29)  LDD1363  [6]
 LDCM0022  KB02 A2780 C99(2.02)  LDD2254  [7]
 LDCM0023  KB03 Jurkat C99(10.01)  LDD0209  [3]
 LDCM0024  KB05 NCI-H1299 C99(3.09)  LDD3343  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C165(0.89)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C165(0.98)  LDD2107  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C165(0.74)  LDD2115  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C165(1.51)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C165(1.09)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C165(0.84)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C165(0.78)  LDD2137  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C165(0.84)  LDD2148  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840