Details of the Target

General Information of Target

Target ID LDTP19388
Target Name MORN repeat-containing protein 1 (MORN1)
Gene Name MORN1
Gene ID 79906
Synonyms
MORN repeat-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKTKDIGDDDTVASEFWSGALSQPSSVPTRPRTPNRDSWRRAWAARGLHPRPSILQPGP
ARLSRARAGGTRCPQRRHGRATFCALGRGIGVRRGPGPRPARIPGLTLTWKRMSARRMQW
AMQTGGRNQTFGGGVPLFWTWLTICCAVWRSLPCRLTHSCSRAFSSAPLKKTKSSMLPPK
QALASAARNLCRGAGCNRQAVAGQLLPSTWSLHAHGLAKEAPILPVKKISRSCSVNNKVS
KKTTKPPTLRSFLSPI
Target Bioclass
Enzyme
Uniprot ID
Q5T089
Ensemble ID
ENST00000378529.7
HGNC ID
HGNC:25852

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.G203W .
ICC8 SNV: p.P302R .
KASUMI2 SNV: p.A479T .
LN18 SNV: p.A486D .
MOLT4 SNV: p.F292L .
NCIH23 SNV: p.A350E .
NUGC3 Deletion: p.A316QfsTer117 .
SUDHL6 SNV: p.Q150Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C172(0.94)  LDD1514  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C172(0.97)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C172(0.90)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C172(0.97)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C172(1.02)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C172(0.94)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C172(0.90)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C172(0.80)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C172(0.94)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C172(1.10)  LDD1594  [1]
 LDCM0412  CL24 HEK-293T C172(1.16)  LDD1616  [1]
 LDCM0425  CL36 HEK-293T C172(1.05)  LDD1629  [1]
 LDCM0438  CL48 HEK-293T C172(0.99)  LDD1642  [1]
 LDCM0452  CL60 HEK-293T C172(1.09)  LDD1655  [1]
 LDCM0465  CL72 HEK-293T C172(1.09)  LDD1668  [1]
 LDCM0478  CL84 HEK-293T C172(1.01)  LDD1681  [1]
 LDCM0491  CL96 HEK-293T C172(0.93)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402