Details of the Target

General Information of Target

Target ID LDTP19358
Target Name Testis-expressed protein 30 (TEX30)
Gene Name TEX30
Gene ID 93081
Synonyms
C13orf27; Testis-expressed protein 30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGFFCDCWPSLEIRALLYAMGCIQSIGGKARVFREGITVIDVKASIDPVPTSIDESSSV
VLRYRTPHFRASAQVVMPPIPKKETWVVGWIQACSHMEFYNQYGEQGMSSWELPDLQEGK
IQAISDSDGVNYPWYGNTTETCTIVGPTKRDSKFIISMNDNFYPSVTWAVPVSESNVAKL
TNIYRDQSFTTWLVATNTSTNDMIILQTLHWRMQLSIEVNPNRPLGQRARLREPIAQDQP
KILSKNEPIPPSALVKPNANDAQVLMWRPKYGQPLVVIPPKHR
Target Bioclass
Other
Uniprot ID
Q5JUR7
Ensemble ID
ENST00000376027.5
HGNC ID
HGNC:25188
ChEMBL ID
CHEMBL2189125

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.A190E DBIA    Probe Info 
CCK81 SNV: p.L127P .
HT115 SNV: p.G68C .
TE4 SNV: p.E5K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.78  LDD0403  [1]
DBIA
 Probe Info  		C166(4.59)  LDD0209  [2]
IPM
 Probe Info  		C166(3.54)  LDD1702  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C113(0.00); C21(0.00); C129(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C113(0.00); C129(0.00); C166(0.00); C21(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C166(0.00); C113(0.00)  LDD0037  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		13.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C166(1.15)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C166(1.53)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C129(1.07)  LDD1510  [7]
 LDCM0270  AC15 HEK-293T C129(0.94)  LDD1513  [7]
 LDCM0277  AC18 HEK-293T C166(1.15)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C166(0.80)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C166(1.23)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C129(1.18)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C129(0.87); C166(1.32)  LDD1520  [7]
 LDCM0283  AC23 HEK-293T C129(1.11)  LDD1522  [7]
 LDCM0286  AC26 HEK-293T C166(0.99)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C166(1.24)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C129(0.90)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C129(0.93); C166(1.37)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C166(1.20)  LDD1529  [7]
 LDCM0292  AC31 HEK-293T C129(0.89)  LDD1531  [7]
 LDCM0295  AC34 HEK-293T C166(1.16)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C166(1.25)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C129(1.10)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C129(1.10); C166(1.71)  LDD1537  [7]
 LDCM0300  AC39 HEK-293T C129(0.98)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C129(1.03)  LDD1540  [7]
 LDCM0304  AC42 HEK-293T C166(1.13)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C166(1.38)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C129(1.18)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C129(1.04); C166(1.56)  LDD1546  [7]
 LDCM0309  AC47 HEK-293T C129(0.92)  LDD1548  [7]
 LDCM0312  AC5 HEK-293T C129(0.97); C166(1.46)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C166(1.16)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C166(1.17)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C129(1.13)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C129(1.10); C166(1.29)  LDD1555  [7]
 LDCM0318  AC55 HEK-293T C129(1.01)  LDD1557  [7]
 LDCM0321  AC58 HEK-293T C166(1.22)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C166(1.28)  LDD1561  [7]
 LDCM0324  AC60 HEK-293T C129(1.07)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C129(0.90); C166(1.33)  LDD1564  [7]
 LDCM0327  AC63 HEK-293T C129(0.96)  LDD1566  [7]
 LDCM0334  AC7 HEK-293T C129(1.07)  LDD1568  [7]
 LDCM0248  AKOS034007472 HEK-293T C129(1.06); C166(1.41)  LDD1511  [7]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0371  CL102 HEK-293T C129(0.82)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C129(1.07)  LDD1576  [7]
 LDCM0375  CL106 HEK-293T C129(1.01)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C129(1.08)  LDD1580  [7]
 LDCM0379  CL11 HEK-293T C129(0.89)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C129(0.82)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C129(0.92)  LDD1585  [7]
 LDCM0384  CL114 HEK-293T C129(0.89)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C129(1.00)  LDD1589  [7]
 LDCM0388  CL118 HEK-293T C129(0.91)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C129(1.04)  LDD1593  [7]
 LDCM0393  CL122 HEK-293T C129(0.86)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C129(0.83)  LDD1598  [7]
 LDCM0397  CL126 HEK-293T C129(0.93)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C129(0.95)  LDD1602  [7]
 LDCM0401  CL14 HEK-293T C129(1.01)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C129(1.06)  LDD1606  [7]
 LDCM0405  CL18 HEK-293T C166(1.62)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C166(0.56)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C129(0.84)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C129(1.11)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C129(0.81); C166(0.85)  LDD1613  [7]
 LDCM0411  CL23 HEK-293T C129(1.00)  LDD1615  [7]
 LDCM0414  CL26 HEK-293T C129(0.99)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C129(0.89)  LDD1619  [7]
 LDCM0418  CL3 HEK-293T C129(1.07)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C166(1.15)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C166(0.73)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C129(0.94)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C129(0.54); C166(0.53)  LDD1626  [7]
 LDCM0424  CL35 HEK-293T C129(0.90)  LDD1628  [7]
 LDCM0428  CL39 HEK-293T C129(1.14)  LDD1632  [7]
 LDCM0432  CL42 HEK-293T C166(1.33)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C166(1.12)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C129(1.06)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C129(0.70); C166(0.80)  LDD1639  [7]
 LDCM0437  CL47 HEK-293T C129(0.92)  LDD1641  [7]
 LDCM0441  CL50 HEK-293T C129(1.04)  LDD1645  [7]
 LDCM0445  CL54 HEK-293T C166(1.16)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C166(0.82)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C129(1.03)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C129(0.67); C166(0.63)  LDD1651  [7]
 LDCM0450  CL59 HEK-293T C129(0.96)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C166(1.26)  LDD1654  [7]
 LDCM0454  CL62 HEK-293T C129(1.17)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C129(1.16)  LDD1658  [7]
 LDCM0458  CL66 HEK-293T C166(1.39)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C166(1.12)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C129(1.10)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C129(0.84); C166(0.74)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C166(1.04)  LDD1665  [7]
 LDCM0464  CL71 HEK-293T C129(0.89)  LDD1667  [7]
 LDCM0467  CL74 HEK-293T C129(1.07)  LDD1670  [7]
 LDCM0471  CL78 HEK-293T C166(1.51)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C166(0.98)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C129(0.75)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C129(1.04)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C129(0.94); C166(0.93)  LDD1678  [7]
 LDCM0477  CL83 HEK-293T C129(0.84)  LDD1680  [7]
 LDCM0480  CL86 HEK-293T C129(0.96)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C129(0.99)  LDD1684  [7]
 LDCM0484  CL9 HEK-293T C129(0.93); C166(0.98)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C166(0.78)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C166(1.07)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C129(0.98)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C129(0.86); C166(1.00)  LDD1691  [7]
 LDCM0490  CL95 HEK-293T C129(0.78)  LDD1693  [7]
 LDCM0493  CL98 HEK-293T C129(0.93)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C129(1.04)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C129(1.22)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C166(3.54)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C129(0.79)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C129(0.96)  LDD1631  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C129(1.05); C21(1.03)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C166(4.59)  LDD0209  [2]
 LDCM0024  KB05 MV4-11 C21(4.68)  LDD3338  [8]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840