Details of the Target

General Information of Target

Target ID LDTP18837
Target Name Putative ribosomal protein eL43-like (RPL37AP8)
Gene Name RPL37AP8
Synonyms
RPL37L; Putative ribosomal protein eL43-like; Putative 60S ribosomal protein L37a-like protein; Ribosomal protein L37a pseudogene 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEQGRETEEEEGGGGASDTAPMLPRGPPDHQASALTCPGWSGPPLLPGRLLAGLLLHLL
LPAAAFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALFSDRGSAALIVFGLLSLPPLLV
LASAVRARLARRLRPLLPPPAGTPGPRRPPGRPDEDEQLCAWV
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL43 family
Uniprot ID
A6NKH3
HGNC ID
HGNC:35645

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C43(2.93); C40(2.93)  LDD2229  [1]
DBIA
 Probe Info  		C43(1.59)  LDD3317  [2]
BTD
 Probe Info  		C43(1.44); C40(1.40)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C40(2.13)  LDD0172  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
NAIA_5
 Probe Info  		C43(0.00); C40(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C40(0.74)  LDD2112  [3]
 LDCM0025  4SU-RNA HEK-293T C40(2.13)  LDD0172  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C43(0.87); C40(1.09)  LDD2113  [3]
 LDCM0022  KB02 42-MG-BA C43(1.47)  LDD2244  [2]
 LDCM0023  KB03 769-P C43(1.98)  LDD2663  [2]
 LDCM0024  KB05 MEL182 C43(1.59)  LDD3317  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C43(0.79); C40(1.70)  LDD2101  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C43(1.03); C40(0.69)  LDD2108  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C43(0.94); C40(0.87)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C43(0.32); C40(0.62)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C43(1.57); C40(1.45)  LDD2119  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C43(0.69); C40(0.88)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C43(0.70); C40(1.04)  LDD2134  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C43(1.44); C40(1.40)  LDD1700  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C40(0.57)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C43(0.74)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C43(2.41); C40(2.05)  LDD2144  [3]

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264