Details of the Target

General Information of Target

Target ID LDTP18480
Target Name CUE domain-containing protein 1 (CUEDC1)
Gene Name CUEDC1
Gene ID 404093
Synonyms
CUE domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCGICCSVNFSAEHFSQDLKEDLLYNLKQRGPNSSKQLLKSDVNYQCLFSAHVLHLRGVL
TTQPVEDERGNVFLWNGEIFSGIKVEAEENDTQILFNYLSSCKNESEILSLFSEVQGPWS
FIYYQASSHYLWFGRDFFGRRSLLWHFSNLGKSFCLSSVGTQTSGLANQWQEVPASGLFR
IDLKSTVISGCIILQLYPWKYISRENIIEENVNSLSQISADLPAFVSVVANEAKLYLEKP
VVPLNMMLPQAALETHCSNISNVPPTREILQVFLTDVHMKEVIQQFIDVLSVAVKKRVLC
LPRDENLTANEVLKTCDRKANVAILFSGGIDSMVIATLADRHIPLDEPIDLLNVAFIAEE
KTMPTTFNREGNKQKNKCEIPSEEFSKDVAAAAADSPNKHVSVPDRITGRAGLKELQAVS
PSRIWNFVEINVSMEELQKLRRTRICHLIRPLDTVLDDSIGCAVWFASRGIGWLVAQEGV
KSYQSNAKVVLTGIGADEQLAGYSRHRVRFQSHGLEGLNKEIMMELGRISSRNLGRDDRV
IGDHGKEARFPFLDENVVSFLNSLPIWEKANLTLPRGIGEKLLLRLAAVELGLTASALLP
KRAMQFGSRIAKMEKINEKASDKCGRLQIMSLENLSIEKETKL
Target Bioclass
Other
Uniprot ID
Q9NWM3
Ensemble ID
ENST00000360238.6
HGNC ID
HGNC:31350

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.E112D .
KMS11 SNV: p.L181I .
KURAMOCHI SNV: p.G19R .
MDST8 Deletion: p.A323PfsTer35 .
NCIH1155 SNV: p.S274N .
NCIH2052 SNV: p.R263Ter .
SUPT1 Insertion: p.E112GfsTer10 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.60  LDD0403  [1]
DBIA
 Probe Info  		C68(2.38)  LDD3360  [2]
AHL-Pu-1
 Probe Info  		C68(2.12)  LDD0170  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C68(2.12)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C68(9.33)  LDD0171  [3]
 LDCM0259  AC14 HEK-293T C68(0.86)  LDD1512  [7]
 LDCM0282  AC22 HEK-293T C68(1.05)  LDD1521  [7]
 LDCM0291  AC30 HEK-293T C68(1.11)  LDD1530  [7]
 LDCM0299  AC38 HEK-293T C68(1.08)  LDD1538  [7]
 LDCM0308  AC46 HEK-293T C68(1.08)  LDD1547  [7]
 LDCM0317  AC54 HEK-293T C68(1.08)  LDD1556  [7]
 LDCM0323  AC6 HEK-293T C68(0.83)  LDD1562  [7]
 LDCM0326  AC62 HEK-293T C68(0.94)  LDD1565  [7]
 LDCM0156  Aniline NCI-H1299 13.60  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C364(0.75)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C68(0.93)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C68(0.65)  LDD1572  [7]
 LDCM0370  CL101 HEK-293T C68(0.86)  LDD1574  [7]
 LDCM0372  CL103 HEK-293T C68(1.00)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C68(0.85)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C68(0.96)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C68(0.86)  LDD1582  [7]
 LDCM0381  CL111 HEK-293T C68(0.97)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C68(0.86)  LDD1587  [7]
 LDCM0385  CL115 HEK-293T C68(0.85)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C68(1.01)  LDD1591  [7]
 LDCM0389  CL119 HEK-293T C68(1.09)  LDD1593  [7]
 LDCM0392  CL121 HEK-293T C68(0.93)  LDD1596  [7]
 LDCM0394  CL123 HEK-293T C68(0.90)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C68(1.03)  LDD1600  [7]
 LDCM0398  CL127 HEK-293T C68(1.07)  LDD1602  [7]
 LDCM0400  CL13 HEK-293T C68(1.11)  LDD1604  [7]
 LDCM0402  CL15 HEK-293T C68(1.03)  LDD1606  [7]
 LDCM0410  CL22 HEK-293T C68(0.95)  LDD1614  [7]
 LDCM0413  CL25 HEK-293T C68(1.09)  LDD1617  [7]
 LDCM0415  CL27 HEK-293T C68(0.89)  LDD1619  [7]
 LDCM0418  CL3 HEK-293T C68(1.11)  LDD1622  [7]
 LDCM0423  CL34 HEK-293T C68(0.89)  LDD1627  [7]
 LDCM0426  CL37 HEK-293T C68(0.83)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C68(0.93)  LDD1632  [7]
 LDCM0436  CL46 HEK-293T C68(0.89)  LDD1640  [7]
 LDCM0439  CL49 HEK-293T C68(1.15)  LDD1643  [7]
 LDCM0449  CL58 HEK-293T C68(0.77)  LDD1652  [7]
 LDCM0453  CL61 HEK-293T C68(1.06)  LDD1656  [7]
 LDCM0455  CL63 HEK-293T C68(1.17)  LDD1658  [7]
 LDCM0463  CL70 HEK-293T C68(1.00)  LDD1666  [7]
 LDCM0466  CL73 HEK-293T C68(0.85)  LDD1669  [7]
 LDCM0476  CL82 HEK-293T C68(0.89)  LDD1679  [7]
 LDCM0479  CL85 HEK-293T C68(1.08)  LDD1682  [7]
 LDCM0481  CL87 HEK-293T C68(1.01)  LDD1684  [7]
 LDCM0489  CL94 HEK-293T C68(0.87)  LDD1692  [7]
 LDCM0492  CL97 HEK-293T C68(1.02)  LDD1695  [7]
 LDCM0494  CL99 HEK-293T C68(0.98)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C68(0.96)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C68(1.04)  LDD1671  [7]
 LDCM0022  KB02 HEK-293T C364(1.17)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C364(1.03)  LDD1497  [7]
 LDCM0024  KB05 NCI-H3122 C68(2.38)  LDD3360  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 E2 (UBE2E2) Ubiquitin-conjugating enzyme family Q96LR5
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Cytoplasmic protein NCK2 (NCK2) . O43639

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402