Details of the Target

General Information of Target

Target ID LDTP18473
Target Name DnaJ homolog subfamily C member 17 (DNAJC17)
Gene Name DNAJC17
Gene ID 55192
Synonyms
DnaJ homolog subfamily C member 17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAPRRDMELLSNSLAAYAHIRANPESFGLYFVLGVCFGLLLTLCLLVISISWAPRPRPR
GPAQRRDPRSSTLEPEDDDEDEEDTVTRLGPDDTLPGPELSAEPDGPLNVNVFTSAEELE
RAQRLEERERILREIWRTGQPDLLGTGTLGPSPTATGTLGRMHYY
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May negatively affect PAX8-induced thyroglobulin/TG transcription.
Uniprot ID
Q9NVM6
Ensemble ID
ENST00000220496.9
HGNC ID
HGNC:25556

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.38  LDD0403  [1]
BTD
 Probe Info  		C38(1.39)  LDD2096  [2]
DBIA
 Probe Info  		C38(1.05)  LDD1511  [3]
ATP probe
 Probe Info  		K264(0.00); K42(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C38(0.00); C179(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C38(0.00); C179(0.00)  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0147  [6]
NAIA_5
 Probe Info  		C38(0.00); C179(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C38(0.95)  LDD1520  [3]
 LDCM0289  AC29 HEK-293T C38(1.01)  LDD1528  [3]
 LDCM0298  AC37 HEK-293T C38(1.00)  LDD1537  [3]
 LDCM0307  AC45 HEK-293T C38(1.06)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C38(0.98)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C38(1.02)  LDD1555  [3]
 LDCM0325  AC61 HEK-293T C38(0.98)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C38(1.05)  LDD1511  [3]
 LDCM0156  Aniline NCI-H1299 12.38  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C179(0.89)  LDD2227  [7]
 LDCM0409  CL21 HEK-293T C38(0.92)  LDD1613  [3]
 LDCM0422  CL33 HEK-293T C38(0.88)  LDD1626  [3]
 LDCM0435  CL45 HEK-293T C38(0.93)  LDD1639  [3]
 LDCM0448  CL57 HEK-293T C38(0.95)  LDD1651  [3]
 LDCM0461  CL69 HEK-293T C38(0.90)  LDD1664  [3]
 LDCM0475  CL81 HEK-293T C38(1.05)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C38(0.90)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C38(0.74)  LDD1691  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C38(1.39)  LDD2096  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C38(0.53)  LDD2104  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C38(1.13)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C38(1.16)  LDD2134  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C38(1.05)  LDD2148  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.