Details of the Target

General Information of Target

Target ID LDTP18446
Target Name Band 4.1-like protein 4A (EPB41L4A)
Gene Name EPB41L4A
Gene ID 64097
Synonyms
EPB41L4; Band 4.1-like protein 4A; Erythrocyte membrane protein band 4.1-like 4A; Protein NBL4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAKVRPSRRSRAQRDRGRRREAARDARAQSPSSGDEPEPSPGKENAGLRGAPPRGAAPA
PRTARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWERRLIKKPR
ESETCPPAEPSENRRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVTVSKGGDRDSDDDS
VLEATSSRDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPGTDKGPALEKSEAK
AGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPAPHRHTPQ
PPPPQPRGLLPTHVPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGKHVSLSPHGPGPHL
STSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQ
SAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDK
YAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVS
TCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAW
QIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPA
SNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEG
SSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLL
EKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEAAKMP
ARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRG
LELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPAL
DGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTPPGPPRSRTT
PLGGLGPGEARDYSPSRNPPEVEAR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Uniprot ID
Q9HCS5
Ensemble ID
ENST00000261486.6
HGNC ID
HGNC:13278

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C605(1.47)  LDD3323  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C104(0.96)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C104(0.97)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C104(0.97)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C104(1.00)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C104(0.99)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C104(0.98)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C104(0.95)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C104(0.87)  LDD1514  [2]
 LDCM0390  CL12 HEK-293T C104(1.19)  LDD1594  [2]
 LDCM0412  CL24 HEK-293T C104(1.24)  LDD1616  [2]
 LDCM0425  CL36 HEK-293T C104(1.23)  LDD1629  [2]
 LDCM0438  CL48 HEK-293T C104(1.20)  LDD1642  [2]
 LDCM0452  CL60 HEK-293T C104(1.15)  LDD1655  [2]
 LDCM0465  CL72 HEK-293T C104(1.13)  LDD1668  [2]
 LDCM0478  CL84 HEK-293T C104(1.29)  LDD1681  [2]
 LDCM0491  CL96 HEK-293T C104(0.97)  LDD1694  [2]
 LDCM0022  KB02 ABC-1 C446(1.44); C605(1.76)  LDD2262  [1]
 LDCM0023  KB03 A-549 C446(0.96)  LDD2677  [1]
 LDCM0024  KB05 SKMEL24 C605(1.47)  LDD3323  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402