Details of the Target

General Information of Target

Target ID LDTP18437
Target Name Vasculin-like protein 1 (GPBP1L1)
Gene Name GPBP1L1
Gene ID 60313
Synonyms
Vasculin-like protein 1; GC-rich promoter-binding protein 1-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLASSKRMNSSSRSQILLRWKSDKAQSGPYNVEKEILTSRFLRDTETCRQNFRNFPYPDL
AGPRKALSQLRELCLKWLRPEIHSKEQILELLVLEQFLTILPGEVRTWVKSQYPESSEEA
VTLVEDLTQILEEEAPQNSTLSQDTPEEDPRGKHAFQTGWLNDLVTKESMTFKDVAVDIT
QEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEILEGPSPEW
ETKAQACTPVEDMSKLTKEETHTIKLEDSYDYDDRLERRGKGGFWKIHTDERGFSLKSVL
SQEYDPTEECLSKYDIYRNNFEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRK
ILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTG
EKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPY
KCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNE
CWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICNICGKA
FSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQG
ANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNECDKDFSQRTCLI
QHQRIHTGEKPYACRICGKTFTQSTNLIQHQRVHTGAKHRN
Target Bioclass
Other
Family
Vasculin family
Subcellular location
Nucleus
Function Possible transcription factor.
Uniprot ID
Q9HC44
Ensemble ID
ENST00000290795.7
HGNC ID
HGNC:28843

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C130(0.95)  LDD1492  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C130(1.06); C365(0.89)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C130(0.99)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C130(1.00)  LDD1510  [1]
 LDCM0277  AC18 HEK-293T C130(1.02); C365(0.86)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C130(1.22)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C130(1.01); C365(0.87)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C130(0.97)  LDD1519  [1]
 LDCM0286  AC26 HEK-293T C130(1.00); C365(0.98)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C130(0.98)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C130(1.08)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C130(0.93)  LDD1529  [1]
 LDCM0295  AC34 HEK-293T C130(0.99); C365(0.74)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C130(1.05)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C130(1.07)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C130(0.92)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C130(1.07); C365(0.98)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C130(1.06)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C130(1.00)  LDD1545  [1]
 LDCM0313  AC50 HEK-293T C130(1.07); C365(0.83)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C130(0.91)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C130(1.06)  LDD1554  [1]
 LDCM0321  AC58 HEK-293T C130(1.10); C365(0.74)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C130(0.96)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C130(1.03)  LDD1563  [1]
 LDCM0369  CL100 HEK-293T C130(1.02)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C130(1.01)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C130(0.95)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C130(0.97)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C130(1.06)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C130(0.87)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C130(0.96)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C130(0.90)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C130(0.94)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C130(1.02)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C130(0.97)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C130(0.96)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C130(0.97)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C130(1.13)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C130(0.93)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C130(1.03)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C130(0.82)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C130(0.86)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C130(1.02)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C130(0.93)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C130(0.82)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C130(1.01)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C130(0.65)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C130(0.88)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C130(1.00)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C130(1.13); C365(0.84)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C130(1.05)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C130(0.85)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C130(1.15)  LDD1612  [1]
 LDCM0414  CL26 HEK-293T C130(0.96)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C130(1.00)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C130(0.92)  LDD1620  [1]
 LDCM0418  CL3 HEK-293T C130(0.92)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C130(1.03); C365(0.84)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C130(1.03)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C130(0.97)  LDD1625  [1]
 LDCM0428  CL39 HEK-293T C130(1.00)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C130(1.02)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C130(0.95)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C130(0.96); C365(0.71)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C130(0.99)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C130(1.10)  LDD1638  [1]
 LDCM0441  CL50 HEK-293T C130(0.98)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C130(1.15)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C130(1.12); C365(0.71)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C130(1.15)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C130(1.09)  LDD1650  [1]
 LDCM0451  CL6 HEK-293T C130(1.08); C365(0.96)  LDD1654  [1]
 LDCM0454  CL62 HEK-293T C130(1.01)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C130(1.02)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C130(1.01)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C130(1.20); C365(0.79)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C130(1.01)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C130(1.08)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C130(1.02)  LDD1665  [1]
 LDCM0467  CL74 HEK-293T C130(1.04)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C130(0.93)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C130(1.13); C365(0.87)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C130(0.97)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C130(1.06)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C130(1.07)  LDD1677  [1]
 LDCM0480  CL86 HEK-293T C130(0.82)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C130(0.94)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C130(1.08)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C130(1.24); C365(1.12)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C130(1.07)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C130(0.94)  LDD1690  [1]
 LDCM0493  CL98 HEK-293T C130(1.04)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C130(0.89)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C130(1.04)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C130(0.94)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C130(0.91)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C130(0.95)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C130(1.07)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C130(1.00)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein c-Fos (FOS) BZIP family P01100
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 11 (CNOT11) CNOT11 family Q9UKZ1

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004