Details of the Target

General Information of Target

Target ID LDTP18375
Target Name Talin rod domain-containing protein 1 (TLNRD1)
Gene Name TLNRD1
Gene ID 59274
Synonyms
MESDC1; Talin rod domain-containing protein 1; Mesoderm development candidate 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPEAFEICPYDPHHRIPLSRFQYHLASCRRKNPKKAKKMATCKYNACHVVPIKNLEEHE
AVCVNRSAVEEEDTENPLKVSPPSSEQNDDTQQVSPCLPSPDIWNVDGANCQHVFVLKTF
FPQKVVCENDTKESARETSPQKILRPGQ
Target Bioclass
Other
Function Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
Uniprot ID
Q9H1K6
Ensemble ID
ENST00000267984.4
HGNC ID
HGNC:13519

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C164(1.09)  LDD1510  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [2]
NAIA_5
 Probe Info  		C125(0.00); C198(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C164(1.09)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C164(1.00)  LDD1513  [1]
 LDCM0280  AC20 HEK-293T C164(0.87)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C164(1.02)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C164(0.89)  LDD1522  [1]
 LDCM0288  AC28 HEK-293T C164(1.03)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C164(1.01)  LDD1528  [1]
 LDCM0292  AC31 HEK-293T C164(1.01)  LDD1531  [1]
 LDCM0297  AC36 HEK-293T C164(1.09)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C164(1.01)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C164(1.09)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C164(1.09)  LDD1540  [1]
 LDCM0306  AC44 HEK-293T C164(1.10)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C164(1.05)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C164(0.97)  LDD1548  [1]
 LDCM0312  AC5 HEK-293T C164(0.99)  LDD1551  [1]
 LDCM0315  AC52 HEK-293T C164(1.02)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C164(1.00)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C164(1.14)  LDD1557  [1]
 LDCM0324  AC60 HEK-293T C164(1.19)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C164(0.99)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C164(0.98)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C164(0.96)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C164(1.08)  LDD1511  [1]
 LDCM0371  CL102 HEK-293T C164(1.20)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C164(1.04)  LDD1579  [1]
 LDCM0379  CL11 HEK-293T C164(1.14)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C164(1.30)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C164(1.22)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C164(1.10)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C164(1.19)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C164(1.09)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C164(1.07)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C164(0.97)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C164(1.28)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C164(1.67)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C164(1.22)  LDD1615  [1]
 LDCM0414  CL26 HEK-293T C164(1.11)  LDD1618  [1]
 LDCM0421  CL32 HEK-293T C164(1.09)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C164(1.27)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C164(1.28)  LDD1628  [1]
 LDCM0434  CL44 HEK-293T C164(1.04)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C164(1.15)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C164(1.26)  LDD1641  [1]
 LDCM0441  CL50 HEK-293T C164(1.14)  LDD1645  [1]
 LDCM0447  CL56 HEK-293T C164(1.26)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C164(1.35)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C164(1.23)  LDD1653  [1]
 LDCM0454  CL62 HEK-293T C164(0.94)  LDD1657  [1]
 LDCM0460  CL68 HEK-293T C164(1.12)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C164(1.13)  LDD1664  [1]
 LDCM0464  CL71 HEK-293T C164(1.29)  LDD1667  [1]
 LDCM0467  CL74 HEK-293T C164(1.08)  LDD1670  [1]
 LDCM0473  CL8 HEK-293T C164(1.44)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C164(0.97)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C164(1.23)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C164(1.25)  LDD1680  [1]
 LDCM0480  CL86 HEK-293T C164(0.99)  LDD1683  [1]
 LDCM0484  CL9 HEK-293T C164(1.07)  LDD1687  [1]
 LDCM0487  CL92 HEK-293T C164(1.27)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C164(1.29)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C164(1.49)  LDD1693  [1]
 LDCM0493  CL98 HEK-293T C164(1.04)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C164(1.05)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebral cavernous malformations 2 protein (CCM2) CCM2 family Q9BSQ5
PRKCA-binding protein (PICK1) . Q9NRD5
Talin rod domain-containing protein 1 (TLNRD1) . Q9H1K6

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264