Details of the Target

General Information of Target

Target ID LDTP18061
Target Name Pleckstrin homology domain-containing family O member 2 (PLEKHO2)
Gene Name PLEKHO2
Gene ID 80301
Synonyms
PLEKHQ1; Pleckstrin homology domain-containing family O member 2; PH domain-containing family O member 2; Pleckstrin homology domain-containing family Q member 1; PH domain-containing family Q member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTPESRDTTDLSPGGTQEMEGIVIVKVEEEDEEDHFQKERNKVESSPQVLSRSTTMNERA
LLSSYLVAYRVAKEKMAHTAAEKIILPACMDMVRTIFDDKSADKLRTIPLSDNTISRRIC
TIAKHLEAMLITRLQSGIDFAIQLDESTDIASCPTLLVYVRYVWQDDFVEDLLCCLNLNS
HITGLDLFTELENCLLGQYKLNWKHCKGISSDGTANMTGKHSRLTEKLLEATHNNAVWNH
CFIHREALVSKEISPSLMDVLKNAVKTVNFIKGSSLNSRLLEIFCSEIGVNHTHLLFHTE
VRWLSQGKVLSRVYELRNEIYIFLVEKQSHLANIFEDDIWVTKLAYLSDIFGILNELSLK
MQGKNNDIFQYLEHILGFQKTLLLWQARLKSNRPSYYMFPTLLQHIEENIINEDCLKEIK
LEILLHLTSLSQTFNYYFPEEKFESLKENIWMKDPFAFQNPESIIELNLEPEEENELLQL
SSSFTLKNYYKILSLSAFWIKIKDDFPLLSRKSILLLLPFTTTYLCELGFSILTRLKTKK
RNRLNSAPDMRVALSSCVPDWKELMNRQAHPSH
Target Bioclass
Other
Uniprot ID
Q8TD55
Ensemble ID
ENST00000323544.5
HGNC ID
HGNC:30026

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R39Q .
CHL1 SNV: p.P242S DBIA    Probe Info 
COLO792 SNV: p.F185L DBIA    Probe Info 
HCC15 SNV: p.E359D .
HCT15 SNV: p.K124R; p.S278I; p.P437H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C135(0.74)  LDD2091  [2]
NAIA_5
 Probe Info  		C388(0.68)  LDD2227  [3]
DBIA
 Probe Info  		C388(36.47)  LDD0209  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C135(0.38)  LDD2132  [2]
 LDCM0545  Acetamide MDA-MB-231 C135(0.51)  LDD2138  [2]
 LDCM0156  Aniline NCI-H1299 12.84  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C135(0.74)  LDD2091  [2]
 LDCM0632  CL-Sc Hep-G2 C388(0.68)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C135(1.03)  LDD1571  [8]
 LDCM0370  CL101 HEK-293T C135(0.99)  LDD1574  [8]
 LDCM0374  CL105 HEK-293T C135(1.04)  LDD1578  [8]
 LDCM0378  CL109 HEK-293T C135(1.04)  LDD1582  [8]
 LDCM0383  CL113 HEK-293T C135(1.08)  LDD1587  [8]
 LDCM0387  CL117 HEK-293T C135(1.01)  LDD1591  [8]
 LDCM0392  CL121 HEK-293T C135(1.09)  LDD1596  [8]
 LDCM0396  CL125 HEK-293T C135(1.01)  LDD1600  [8]
 LDCM0400  CL13 HEK-293T C135(1.18)  LDD1604  [8]
 LDCM0413  CL25 HEK-293T C135(1.04)  LDD1617  [8]
 LDCM0426  CL37 HEK-293T C135(1.01)  LDD1630  [8]
 LDCM0439  CL49 HEK-293T C135(1.01)  LDD1643  [8]
 LDCM0453  CL61 HEK-293T C135(1.03)  LDD1656  [8]
 LDCM0466  CL73 HEK-293T C135(1.02)  LDD1669  [8]
 LDCM0479  CL85 HEK-293T C135(0.95)  LDD1682  [8]
 LDCM0492  CL97 HEK-293T C135(0.91)  LDD1695  [8]
 LDCM0022  KB02 42-MG-BA C9(2.19); C295(1.83)  LDD2244  [9]
 LDCM0023  KB03 Jurkat C388(36.47)  LDD0209  [4]
 LDCM0024  KB05 MKN45 C9(1.80); C295(0.47)  LDD3332  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C135(0.72)  LDD2121  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C135(1.03)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C135(1.86)  LDD2093  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C135(1.06)  LDD2098  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C135(0.60)  LDD2104  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C135(0.81)  LDD2107  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C135(0.46)  LDD2114  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C135(0.68)  LDD2120  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C135(0.96)  LDD2128  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C135(0.76)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C135(1.62)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C135(1.62)  LDD2136  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C135(1.03)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C135(0.96)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C135(0.76)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C135(3.34)  LDD2144  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C135(1.73)  LDD2147  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C135(0.86)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-C (CCNC) Cyclin family P24863

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840