Details of the Target

General Information of Target

Target ID LDTP17772
Target Name Fibrous sheath-interacting protein 1 (FSIP1)
Gene Name FSIP1
Gene ID 161835
Synonyms
Fibrous sheath-interacting protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLEGSWINRREDKLGVYSLVHFSPKMLGSVATTLPLSSSNSSGMPLGYYLSSPQISRVTI
STTGQLTSKATVGSCSRVENSLDASPFSVPKKQDESPMIGDGEDYFLSLFGDSKKLTAHS
NYTQKTLKYFSMILEEVGQFTSSSLGDVEIAEVNVKGLFVKLINSSLDKEMAIGDHILQQ
NVNGQTISLYRFLPNIVMQANSTVTVWAAASEAKHQPPSDFLWKEQDKFRASPDCITILC
KPNGQAIAWYTPIHWKQAWEKLDADVEFNRCSVVSPTFRKRVFQWTASTATITKEKQDQP
KKDISNYQVEQAQVLLKREKEIPPTVFPNRSPWCQNPYVSAHPYCPLIEPHNTSTAGGRL
DRQPRTRSTRPNRASGSKKKKTSESQKQ
Target Bioclass
Other
Family
FSIP1 family
Uniprot ID
Q8NA03
Ensemble ID
ENST00000350221.4
HGNC ID
HGNC:21674

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C476(3.80)  LDD3319  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C76(1.09)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C76(1.08)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C76(1.07)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C76(1.06)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C76(1.14)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C76(1.10)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C76(1.03)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C76(1.28)  LDD1514  [2]
 LDCM0390  CL12 HEK-293T C76(1.34)  LDD1594  [2]
 LDCM0412  CL24 HEK-293T C76(1.40)  LDD1616  [2]
 LDCM0425  CL36 HEK-293T C76(1.32)  LDD1629  [2]
 LDCM0438  CL48 HEK-293T C76(1.21)  LDD1642  [2]
 LDCM0452  CL60 HEK-293T C76(1.36)  LDD1655  [2]
 LDCM0465  CL72 HEK-293T C76(1.43)  LDD1668  [2]
 LDCM0478  CL84 HEK-293T C76(1.44)  LDD1681  [2]
 LDCM0491  CL96 HEK-293T C76(1.16)  LDD1694  [2]
 LDCM0022  KB02 BRX401 C476(1.47)  LDD2275  [1]
 LDCM0023  KB03 Detroit 562 C476(2.98)  LDD2733  [1]
 LDCM0024  KB05 MEWO C476(3.80)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402