Details of the Target

General Information of Target

Target ID LDTP17695
Target Name T-cell activation inhibitor, mitochondrial (TCAIM)
Gene Name TCAIM
Gene ID 285343
Synonyms
C3orf23; TOAG1; T-cell activation inhibitor, mitochondrial; Tolerance associated gene-1 protein; TOAG-1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKAHHVKTGTCEVVALHRCCNKNKIEE
RSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCLEGEECKVLPDRKGWSCSS
GNKVKTTRVTH
Target Bioclass
Other
Subcellular location
Mitochondrion
Function May regulate T-cell apoptosis.
Uniprot ID
Q8N3R3
Ensemble ID
ENST00000342649.9
HGNC ID
HGNC:25241

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.G492E .
HCT116 Insertion: p.D220RfsTer2 .
ICC3 SNV: p.R362Ter .
KASUMI2 SNV: p.N71H .
KMCH1 SNV: p.R356G .
MCC13 SNV: p.W293Ter .
SKOV3 Deletion: p.A263QfsTer14 .
SNGM Deletion: p.A263QfsTer14 .
SW1116 SNV: p.L128F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C392(0.89)  LDD1511  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C392(0.90)  LDD1520  [1]
 LDCM0284  AC24 HEK-293T C392(0.89)  LDD1523  [1]
 LDCM0289  AC29 HEK-293T C392(1.02)  LDD1528  [1]
 LDCM0293  AC32 HEK-293T C392(1.48)  LDD1532  [1]
 LDCM0298  AC37 HEK-293T C392(1.32)  LDD1537  [1]
 LDCM0302  AC40 HEK-293T C392(1.02)  LDD1541  [1]
 LDCM0307  AC45 HEK-293T C392(1.14)  LDD1546  [1]
 LDCM0310  AC48 HEK-293T C392(1.35)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C392(1.01)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C392(0.86)  LDD1555  [1]
 LDCM0319  AC56 HEK-293T C392(1.11)  LDD1558  [1]
 LDCM0325  AC61 HEK-293T C392(0.80)  LDD1564  [1]
 LDCM0328  AC64 HEK-293T C392(0.91)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C392(0.74)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C392(0.89)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C392(0.73)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C392(1.01)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C392(0.91)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C392(0.97)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C392(0.75)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C392(0.89)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C392(1.36)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C392(1.02)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C392(0.72)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C392(1.05)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C392(0.86)  LDD1604  [1]
 LDCM0409  CL21 HEK-293T C392(0.77)  LDD1613  [1]
 LDCM0412  CL24 HEK-293T C392(1.03)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C392(0.97)  LDD1617  [1]
 LDCM0422  CL33 HEK-293T C392(0.65)  LDD1626  [1]
 LDCM0425  CL36 HEK-293T C392(1.20)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C392(0.89)  LDD1630  [1]
 LDCM0435  CL45 HEK-293T C392(0.86)  LDD1639  [1]
 LDCM0438  CL48 HEK-293T C392(0.80)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C392(0.90)  LDD1643  [1]
 LDCM0448  CL57 HEK-293T C392(0.65)  LDD1651  [1]
 LDCM0452  CL60 HEK-293T C392(0.91)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C392(1.42)  LDD1656  [1]
 LDCM0461  CL69 HEK-293T C392(0.71)  LDD1664  [1]
 LDCM0465  CL72 HEK-293T C392(0.86)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C392(0.70)  LDD1669  [1]
 LDCM0475  CL81 HEK-293T C392(0.75)  LDD1678  [1]
 LDCM0478  CL84 HEK-293T C392(0.86)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C392(1.23)  LDD1682  [1]
 LDCM0484  CL9 HEK-293T C392(0.81)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C392(0.95)  LDD1691  [1]
 LDCM0491  CL96 HEK-293T C392(1.05)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C392(0.82)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255