Details of the Target

General Information of Target

Target ID LDTP17684
Target Name Sex comb on midleg-like protein 4 (SCML4)
Gene Name SCML4
Gene ID 256380
Synonyms
Sex comb on midleg-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAMGEPE
PPGPDVYQLACNGRALEEPAEEEVLEVEAACEKHTRRKTRPPVRLVPKVKFEKVEEEEQE
VYEVSVPGDDKDAGPAEAPAEAASGGCDALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRP
ELNVAPYDPHFPAPARDGFPEPSMALPGPEALPTECGFEPPHLAPLSDPEAPSMESPEPV
KPEQGFVWQEASEFEADTAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMC
EKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAF
TQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLT
QLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQ
HSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIV
HSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGV
MDIGLDSQDPMMELTGTDPSELDGQQEMEDFEENAYSYASVDSSAEASVLTEQAMKEMAY
YNVL
Target Bioclass
Other
Family
SCM family
Subcellular location
Nucleus
Function
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.
Uniprot ID
Q8N228
Ensemble ID
ENST00000369020.8
HGNC ID
HGNC:21397

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.G8R .
CAOV3 SNV: p.R9K .
HEC1 SNV: p.S311N .
LOXIMVI SNV: p.S297F .
NCIH2172 SNV: p.P240T .
OVKATE SNV: p.V85I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C324(2.60)  LDD3419  [1]
AHL-Pu-1
 Probe Info  		C269(2.38)  LDD0171  [2]
IA-alkyne
 Probe Info  		C324(5.36)  LDD1705  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C269(2.38)  LDD0171  [2]
 LDCM0625  F8 Ramos C211(1.19)  LDD2187  [4]
 LDCM0573  Fragment11 Ramos C211(10.94)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C211(0.50)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C211(0.88)  LDD2192  [4]
 LDCM0579  Fragment20 Ramos C211(0.46)  LDD2194  [4]
 LDCM0582  Fragment23 Ramos C211(0.54)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C211(0.35)  LDD2197  [4]
 LDCM0588  Fragment30 Ramos C211(0.32)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C211(0.28)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C211(2.47)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C211(1.42)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C211(0.47)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C211(0.74)  LDD2184  [4]
 LDCM0614  Fragment56 Ramos C211(0.90)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C211(0.53)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C211(0.62)  LDD2188  [4]
 LDCM0022  KB02 Ramos C211(0.31)  LDD2182  [4]
 LDCM0023  KB03 Ramos C211(1.01)  LDD2183  [4]
 LDCM0024  KB05 SH-4 C324(2.60)  LDD3419  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RIPOR family member 3 (RIPOR3) RIPOR family Q96MK2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578