Details of the Target

General Information of Target

Target ID LDTP17658
Target Name REST corepressor 2 (RCOR2)
Gene Name RCOR2
Gene ID 283248
Synonyms
REST corepressor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVVMKFFRWVRRAWQRIISWVFFWRQKIKPTISGHPDSKKHSLKKMEKTLQVVETLRLV
ELPKEAKPKLGESPELADPCVLAKTTEETEVELGQQGQSLLQLPRTAVKSVSTLMVSALQ
SGWQMCSWKSSVSSASVSSQVRTQSPLKTPEAELLWEVYLVLWAVRKHLRRLYRRQERHR
RHHVRCHAAPRPNPAQSLKLDAQSPL
Target Bioclass
Transcription factor
Family
CoREST family
Subcellular location
Nucleus
Function May act as a component of a corepressor complex that represses transcription.
Uniprot ID
Q8IZ40
Ensemble ID
ENST00000301459.5
HGNC ID
HGNC:27455

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C59(1.10)  LDD1511  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C59(1.10)  LDD1520  [1]
 LDCM0284  AC24 HEK-293T C59(0.96)  LDD1523  [1]
 LDCM0289  AC29 HEK-293T C59(1.11)  LDD1528  [1]
 LDCM0293  AC32 HEK-293T C59(0.95)  LDD1532  [1]
 LDCM0298  AC37 HEK-293T C59(1.05)  LDD1537  [1]
 LDCM0302  AC40 HEK-293T C59(0.98)  LDD1541  [1]
 LDCM0307  AC45 HEK-293T C59(0.99)  LDD1546  [1]
 LDCM0310  AC48 HEK-293T C59(1.11)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C59(0.94)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C59(0.97)  LDD1555  [1]
 LDCM0319  AC56 HEK-293T C59(1.06)  LDD1558  [1]
 LDCM0325  AC61 HEK-293T C59(0.98)  LDD1564  [1]
 LDCM0328  AC64 HEK-293T C59(1.05)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C59(1.01)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C59(1.10)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C59(1.02)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C59(0.98)  LDD1594  [1]
 LDCM0409  CL21 HEK-293T C59(1.00)  LDD1613  [1]
 LDCM0412  CL24 HEK-293T C59(1.04)  LDD1616  [1]
 LDCM0422  CL33 HEK-293T C59(0.86)  LDD1626  [1]
 LDCM0425  CL36 HEK-293T C59(0.84)  LDD1629  [1]
 LDCM0435  CL45 HEK-293T C59(1.01)  LDD1639  [1]
 LDCM0438  CL48 HEK-293T C59(0.86)  LDD1642  [1]
 LDCM0448  CL57 HEK-293T C59(0.63)  LDD1651  [1]
 LDCM0452  CL60 HEK-293T C59(0.92)  LDD1655  [1]
 LDCM0461  CL69 HEK-293T C59(1.06)  LDD1664  [1]
 LDCM0465  CL72 HEK-293T C59(0.98)  LDD1668  [1]
 LDCM0475  CL81 HEK-293T C59(1.00)  LDD1678  [1]
 LDCM0478  CL84 HEK-293T C59(0.96)  LDD1681  [1]
 LDCM0484  CL9 HEK-293T C59(1.04)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C59(0.98)  LDD1691  [1]
 LDCM0491  CL96 HEK-293T C59(1.17)  LDD1694  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853