Details of the Target

General Information of Target

Target ID LDTP17451
Target Name Transmembrane protein 184A (TMEM184A)
Gene Name TMEM184A
Gene ID 202915
Synonyms
Transmembrane protein 184A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQKHPGERGLYGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPK
HTQHPNPAHWLDPSHGPPGGPGPPRDAEDPDQSETSSEEESGVDQELSKENETGNQKDGN
SFLSIPSACNCQGTPGIPEGPYSEGGNGSSSNFCHHCTSPALGEDELEEEYDDEESLKFP
SDFSRVSSGKKPPSRRQRHRFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRKGLGLWG
AEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGG
WAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLALALFLGFLQLGWRFLVGLGDRLGWRD
KATWLFSWLDSPALQRCLTLLRDSRPWQRLVRIVQWGWLELPWVKQNINRQGNAPVASGR
YCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRA
EEAFKVLRAAWDIVSNAEKRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRC
QGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEW
AGCQRVGISPDTHRVPYHISFGSRIPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPN
GNFFAAPQPAPGAAAASKPNSTVPKGEAKPKRRKKVRRPFQR
Target Bioclass
Transporter and channel
Family
TMEM184 family
Subcellular location
Cell membrane
Function Acts as a heparin receptor in vascular cells. May be involved in vesicle transport in exocrine cells and Sertoli cells.
Uniprot ID
Q6ZMB5
Ensemble ID
ENST00000297477.10
HGNC ID
HGNC:28797

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C326(0.91)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C326(0.91)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C326(0.92)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C326(1.01)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C326(1.02)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C326(0.78)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C326(0.92)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C326(1.06)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C326(1.00)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C326(0.84)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C326(1.18)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C326(0.93)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C326(0.94)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C326(0.85)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C326(0.97)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C326(1.05)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C326(0.98)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C326(0.78)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C326(0.82)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C326(1.06)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C326(1.26)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C326(1.10)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C326(1.21)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C326(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C326(1.29)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C326(1.20)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C326(1.51)  LDD0601  [1]
 LDCM0323  AC6 HCT 116 C326(0.87)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C326(0.89)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C326(0.91)  LDD0662  [1]
 LDCM0365  AC98 HCT 116 C326(0.97)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C326(1.04)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C326(0.93)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C326(0.89)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C326(0.96)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C326(0.86)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C326(1.07)  LDD0685  [1]
 LDCM0370  CL101 HCT 116 C326(0.84)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C326(0.98)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C326(0.87)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C326(0.86)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C326(1.02)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C326(1.35)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C326(1.26)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C326(1.41)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C326(1.39)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C326(1.12)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C326(1.15)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C326(1.28)  LDD0698  [1]
 LDCM0390  CL12 HCT 116 C326(1.29)  LDD0707  [1]
 LDCM0400  CL13 HCT 116 C326(1.10)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C326(1.12)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C326(0.98)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C326(1.02)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C326(0.98)  LDD0735  [1]
 LDCM0429  CL4 HCT 116 C326(0.96)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C326(1.12)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C326(1.18)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C326(1.26)  LDD0779  [1]
 LDCM0473  CL8 HCT 116 C326(1.27)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C326(1.29)  LDD0801  [1]
 LDCM0022  KB02 22RV1 C326(1.64)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C326(3.13)  LDD2660  [2]
 LDCM0024  KB05 MEWO C326(1.19)  LDD3319  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840