Details of the Target

General Information of Target

Target ID LDTP17425
Target Name Protein shisa-like-2A (SHISAL2A)
Gene Name SHISAL2A
Gene ID 348378
Synonyms
FAM159A; Protein shisa-like-2A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPKKLSCLRSLLLPLSLTLLLPQADTRSFVVDRGHDRFLLDGAPFRYVSGSLHYFRVPR
VLWADRLLKMRWSGLNAIQFYVPWNYHEPQPGVYNFNGSRDLIAFLNEAALANLLVILRP
GPYICAEWEMGGLPSWLLRKPEIHLRTSDPDFLAAVDSWFKVLLPKIYPWLYHNGGNIIS
IQVENEYGSYRACDFSYMRHLAGLFRALLGEKILLFTTDGPEGLKCGSLRGLYTTVDFGP
ADNMTKIFTLLRKYEPHGPLVNSEYYTGWLDYWGQNHSTRSVSAVTKGLENMLKLGASVN
MYMFHGGTNFGYWNGADKKGRFLPITTSYDYDAPISEAGDPTPKLFALRDVISKFQEVPL
GPLPPPSPKMMLGPVTLHLVGHLLAFLDLLCPRGPIHSILPMTFEAVKQDHGFMLYRTYM
THTIFEPTPFWVPNNGVHDRAYVMVDGVFQGVVERNMRDKLFLTGKLGSKLDILVENMGR
LSFGSNSSDFKGLLKPPILGQTILTQWMMFPLKIDNLVKWWFPLQLPKWPYPQAPSGPTF
YSKTFPILGSVGDTFLYLPGWTKGQVWINGFNLGRYWTKQGPQQTLYVPRFLLFPRGALN
KITLLELEDVPLQPQVQFLDKPILNSTSTLHRTHINSLSADTLSASEPMELSGH
Target Bioclass
Other
Family
Shisa family
Subcellular location
Membrane
Uniprot ID
Q6UWV7
Ensemble ID
ENST00000517870.2
HGNC ID
HGNC:28757

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.V73A .
HT115 SNV: p.D45N .
NCIH1155 SNV: p.V9M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C21(0.92)  LDD2094  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C21(0.92)  LDD2094  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C21(0.70)  LDD2096  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C21(1.18)  LDD2105  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C21(0.68)  LDD2106  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C21(2.16)  LDD2110  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C21(0.64)  LDD2116  [1]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C21(0.58)  LDD2118  [1]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C21(0.97)  LDD2151  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C21(1.50)  LDD2153  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761