Details of the Target

General Information of Target

Target ID LDTP17281
Target Name Protein SLX4IP (SLX4IP)
Gene Name SLX4IP
Gene ID 128710
Synonyms
C20orf94; Protein SLX4IP; SLX4-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNS
LRHNLSFNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHTHLH
AGSTKSAPGAGPGGHLHPHHHHHPHHHHHHHAAAHHHHHHHPPQPPPPPPPPPPHMVHYF
HQQPPTAPQPPPHLPSQPPQQPPQQSQPQQPSHPGKMQEAAAVAAAAAAAAAAAVGSVGR
LSQFPPYGLGSAAAAAAAAAASTSGFKHPFAIENIIGRDYKGVLQAGGLPLASVMHHLGY
PVPGQLGNVVSSVWPHVGVMDSVAAAAAAAAAAGVPVGPEYGAFGVPVKSLCHSASQSLP
AMPVPIKPTPALPPVSALQPGLTVPAASQQPPAPSTVCSAAAASPVASLLEPTAPTSAES
KGGSLHSVLVHS
Target Bioclass
Other
Family
SLX4IP family
Uniprot ID
Q5VYV7
Ensemble ID
ENST00000334534.10
HGNC ID
HGNC:16225

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C274(0.89); C276(0.89); C282(0.89)  LDD0078  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
IPM
 Probe Info  		C274(0.00); C282(0.00); C299(0.00)  LDD2156  [4]
Phosphinate-6
 Probe Info  		C299(0.00); C108(0.00)  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C299(1.00)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C299(0.97)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C299(1.06); C42(0.85)  LDD1510  [6]
 LDCM0270  AC15 HEK-293T C299(0.98)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C299(0.99)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C299(1.48)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C299(0.89)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C299(1.07); C42(0.87)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C299(1.01)  LDD1520  [6]
 LDCM0283  AC23 HEK-293T C299(1.06)  LDD1522  [6]
 LDCM0286  AC26 HEK-293T C299(0.88)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C299(1.22)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C299(1.07); C42(0.91)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C299(0.91)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C299(0.77)  LDD1529  [6]
 LDCM0292  AC31 HEK-293T C299(1.04)  LDD1531  [6]
 LDCM0295  AC34 HEK-293T C299(1.12)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C299(1.20)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C299(1.05); C42(0.85)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C299(1.03)  LDD1537  [6]
 LDCM0300  AC39 HEK-293T C299(1.10)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C299(0.92); C42(0.82)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C299(1.14)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C299(1.04)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C299(0.97); C42(0.85)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C299(1.08)  LDD1546  [6]
 LDCM0309  AC47 HEK-293T C299(1.08)  LDD1548  [6]
 LDCM0312  AC5 HEK-293T C299(0.76)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C299(0.97)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C299(0.87)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C299(1.07); C42(0.89)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C299(0.98)  LDD1555  [6]
 LDCM0318  AC55 HEK-293T C299(1.12)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C299(0.92)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C299(0.96)  LDD1561  [6]
 LDCM0324  AC60 HEK-293T C299(0.92); C42(0.90)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C299(1.02)  LDD1564  [6]
 LDCM0327  AC63 HEK-293T C299(0.97)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C299(0.77)  LDD1568  [6]
 LDCM0248  AKOS034007472 HEK-293T C299(0.97)  LDD1511  [6]
 LDCM0020  ARS-1620 HCC44 C274(0.89); C276(0.89); C282(0.89)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C299(0.94); C42(0.96)  LDD1571  [6]
 LDCM0370  CL101 HEK-293T C299(0.90); C42(1.02)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C299(1.14)  LDD1575  [6]
 LDCM0374  CL105 HEK-293T C299(1.04); C42(0.92)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C299(1.02)  LDD1579  [6]
 LDCM0378  CL109 HEK-293T C299(0.98); C42(0.94)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C299(1.16)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C299(1.14)  LDD1584  [6]
 LDCM0383  CL113 HEK-293T C299(1.05); C42(0.95)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C299(1.10)  LDD1588  [6]
 LDCM0387  CL117 HEK-293T C299(1.02); C42(0.96)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C299(1.32)  LDD1592  [6]
 LDCM0392  CL121 HEK-293T C299(1.04); C42(0.92)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C299(1.05)  LDD1597  [6]
 LDCM0396  CL125 HEK-293T C299(0.98); C42(0.93)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C299(0.95)  LDD1601  [6]
 LDCM0400  CL13 HEK-293T C299(1.12); C42(1.06)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C299(0.98)  LDD1605  [6]
 LDCM0405  CL18 HEK-293T C299(1.05)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C299(1.24)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C299(1.06)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C299(1.19); C42(0.90)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C299(1.05)  LDD1613  [6]
 LDCM0411  CL23 HEK-293T C299(1.20)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C299(0.87); C42(1.04)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C299(1.01)  LDD1618  [6]
 LDCM0419  CL30 HEK-293T C299(0.95)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C299(1.17)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C299(1.20); C42(0.82)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C299(1.18)  LDD1626  [6]
 LDCM0424  CL35 HEK-293T C299(1.24)  LDD1628  [6]
 LDCM0426  CL37 HEK-293T C299(0.98); C42(0.92)  LDD1630  [6]
 LDCM0432  CL42 HEK-293T C299(0.97)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C299(0.93)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C299(1.09); C42(0.91)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C299(1.26)  LDD1639  [6]
 LDCM0437  CL47 HEK-293T C299(1.17)  LDD1641  [6]
 LDCM0439  CL49 HEK-293T C299(0.90); C42(0.93)  LDD1643  [6]
 LDCM0441  CL50 HEK-293T C299(1.03)  LDD1645  [6]
 LDCM0445  CL54 HEK-293T C299(0.93)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C299(0.92)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C299(1.16); C42(0.86)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C299(1.27)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C299(1.12)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C299(0.99)  LDD1654  [6]
 LDCM0453  CL61 HEK-293T C299(1.05); C42(0.91)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C299(1.04)  LDD1657  [6]
 LDCM0458  CL66 HEK-293T C299(0.94)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C299(1.03)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C299(1.12); C42(0.96)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C299(1.20)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C299(1.10)  LDD1665  [6]
 LDCM0464  CL71 HEK-293T C299(1.25)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C299(0.88); C42(0.98)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C299(1.12)  LDD1670  [6]
 LDCM0471  CL78 HEK-293T C299(1.11)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C299(0.99)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C299(0.93); C42(3.49)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C299(1.01); C42(0.96)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C299(1.23)  LDD1678  [6]
 LDCM0477  CL83 HEK-293T C299(1.23)  LDD1680  [6]
 LDCM0479  CL85 HEK-293T C299(0.81); C42(0.97)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C299(0.91)  LDD1683  [6]
 LDCM0484  CL9 HEK-293T C299(1.10)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C299(0.90)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C299(0.94)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C299(0.97); C42(1.28)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C299(1.13)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C299(1.26)  LDD1693  [6]
 LDCM0492  CL97 HEK-293T C299(0.63); C42(1.21)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C299(0.72)  LDD1696  [6]
 LDCM0427  Fragment51 HEK-293T C299(1.13)  LDD1631  [6]
 LDCM0021  THZ1 HCT 116 C274(0.90); C276(0.90); C282(0.90)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Structure-specific endonuclease subunit SLX4 (SLX4) SLX4 family Q8IY92

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402