Details of the Target

General Information of Target

Target ID LDTP17237
Target Name Divergent protein kinase domain 1A (DIPK1A)
Gene Name DIPK1A
Gene ID 388650
Synonyms
FAM69A; Divergent protein kinase domain 1A; Protein FAM69A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPELRVEGWKALHELNPRAA
DEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSLCAAVNRALDEGIPITSAS
YYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILLEKFGGSFLNCVRESENSAQK
LMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADY
RLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQK
GEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY
Target Bioclass
Other
Family
DIPK family
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
Q5T7M9
Ensemble ID
ENST00000370310.5
HGNC ID
HGNC:32213

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K13(5.52); K66(6.25)  LDD0277  [1]
DBIA
 Probe Info  		C6(1.05)  LDD1510  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
AOyne
 Probe Info  		13.20  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C6(1.05)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C6(0.98)  LDD1513  [2]
 LDCM0280  AC20 HEK-293T C6(1.09)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C6(0.88)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C6(0.96)  LDD1522  [2]
 LDCM0288  AC28 HEK-293T C6(0.96)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C6(0.94)  LDD1528  [2]
 LDCM0292  AC31 HEK-293T C6(0.95)  LDD1531  [2]
 LDCM0297  AC36 HEK-293T C6(1.03)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C6(0.96)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C6(1.10)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C6(1.09)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C6(1.10)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C6(0.93)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C6(1.02)  LDD1548  [2]
 LDCM0312  AC5 HEK-293T C6(0.97)  LDD1551  [2]
 LDCM0315  AC52 HEK-293T C6(1.05)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C6(0.98)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C6(1.03)  LDD1557  [2]
 LDCM0324  AC60 HEK-293T C6(1.04)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C6(1.07)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C6(1.03)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C6(0.92)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C6(0.93)  LDD1511  [2]
 LDCM0371  CL102 HEK-293T C6(1.22)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C6(1.17)  LDD1579  [2]
 LDCM0379  CL11 HEK-293T C6(1.12)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C6(1.75)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C6(1.34)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C6(1.28)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C6(1.21)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C6(1.10)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C6(0.98)  LDD1605  [2]
 LDCM0407  CL2 HEK-293T C6(1.15)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C6(1.08)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C6(1.16)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C6(0.98)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C6(0.97)  LDD1618  [2]
 LDCM0421  CL32 HEK-293T C6(1.06)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C6(1.01)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C6(1.00)  LDD1628  [2]
 LDCM0434  CL44 HEK-293T C6(1.00)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C6(1.18)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C6(0.97)  LDD1641  [2]
 LDCM0441  CL50 HEK-293T C6(1.45)  LDD1645  [2]
 LDCM0447  CL56 HEK-293T C6(1.11)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C6(1.07)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C6(1.11)  LDD1653  [2]
 LDCM0454  CL62 HEK-293T C6(1.08)  LDD1657  [2]
 LDCM0460  CL68 HEK-293T C6(1.22)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C6(1.04)  LDD1664  [2]
 LDCM0464  CL71 HEK-293T C6(1.00)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C6(0.91)  LDD1670  [2]
 LDCM0473  CL8 HEK-293T C6(1.54)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C6(0.96)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C6(1.02)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C6(1.16)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C6(1.29)  LDD1683  [2]
 LDCM0484  CL9 HEK-293T C6(0.89)  LDD1687  [2]
 LDCM0487  CL92 HEK-293T C6(1.45)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C6(1.11)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C6(1.27)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C6(1.35)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C6(1.25)  LDD1631  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.