Details of the Target

General Information of Target

Target ID LDTP17212
Target Name Zinc finger and BTB domain-containing protein 41 (ZBTB41)
Gene Name ZBTB41
Gene ID 360023
Synonyms
FRBZ1; Zinc finger and BTB domain-containing protein 41
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDIDQGDSSGSSPPRAPPLP
TGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQTPSTSARAEAPPSLGPGAS
PPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSPGHSTGSQRPPDSPGAPPRSP
SRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAKLMAKAGQEELGPGPAGAPEPGP
RSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAKLHTVSTTVWEALPDVSRAKSDMAV
STPASEPQPDRDMAVSTPASEPQSDRDMAVSTPASEPQPDTDMAVSTPASEPQPDRDMAV
SIPASKPQSDTAVSTPASEPQSSVALSTPISKPQLDTDVAVSTPASKHGLDVALPTAGPV
AKLEVASSPPVSEAVPRMTESSGLVSTPVPRADAAGLAWPPTRRAGPDVVEMEAVVSEPS
AGAPGCCSGAPALGLTQVPRKKKVRFSVAGPSPNKPGSGQASARPSAPQTATGAHGGPGA
WEAVAVGPRPHQPRILKHLPRPPPSAVTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEA
AAAGQDPAGVQWPDMCEFFFPDVGAQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVY
EHFFFGEDRLEGVLGPAVPLPLQALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELR
GPVPSFAFSQNDMCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQG
RRSHSPSPSS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q5SVQ8
Ensemble ID
ENST00000367405.5
HGNC ID
HGNC:24819

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.C88LfsTer2
SNV: p.D599N		 .
COLO829 SNV: p.F164V .
DEL SNV: p.I455F .
HCC70 SNV: p.C636Y DBIA    Probe Info 
HCT15 SNV: p.L91I .
HT115 SNV: p.K713N .
KPNYN SNV: p.R381C DBIA    Probe Info 
KYSE30 SNV: p.E346Ter; p.R585C .
NCIH1703 SNV: p.D880Y DBIA    Probe Info 
NUGC3 Deletion: p.M243CfsTer38 .
RKO Deletion: p.I360YfsTer14
SNV: p.V7A		 .
SHP77 SNV: p.V382F; p.G542D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C539(1.54)  LDD3316  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C539(1.04)  LDD1508  [2]
 LDCM0259  AC14 HEK-293T C539(1.12)  LDD1512  [2]
 LDCM0277  AC18 HEK-293T C539(0.99)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C539(0.95)  LDD1518  [2]
 LDCM0282  AC22 HEK-293T C539(0.93)  LDD1521  [2]
 LDCM0286  AC26 HEK-293T C539(0.95)  LDD1525  [2]
 LDCM0291  AC30 HEK-293T C539(1.01)  LDD1530  [2]
 LDCM0295  AC34 HEK-293T C539(0.98)  LDD1534  [2]
 LDCM0299  AC38 HEK-293T C539(1.07)  LDD1538  [2]
 LDCM0304  AC42 HEK-293T C539(1.08)  LDD1543  [2]
 LDCM0308  AC46 HEK-293T C539(1.14)  LDD1547  [2]
 LDCM0313  AC50 HEK-293T C539(1.02)  LDD1552  [2]
 LDCM0317  AC54 HEK-293T C539(1.04)  LDD1556  [2]
 LDCM0321  AC58 HEK-293T C539(1.02)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C539(1.14)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C539(1.04)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C539(1.16)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C807(0.88)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C807(1.25)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C807(0.65)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C807(0.94)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C807(0.70)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C807(0.76)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C807(0.74)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C807(0.95)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C807(0.86)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C539(1.13)  LDD1609  [2]
 LDCM0410  CL22 HEK-293T C539(1.40)  LDD1614  [2]
 LDCM0416  CL28 HEK-293T C807(1.26)  LDD1620  [2]
 LDCM0419  CL30 HEK-293T C539(1.14)  LDD1623  [2]
 LDCM0423  CL34 HEK-293T C539(1.23)  LDD1627  [2]
 LDCM0429  CL4 HEK-293T C807(0.85)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C807(1.25)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C539(1.05)  LDD1636  [2]
 LDCM0436  CL46 HEK-293T C539(1.18)  LDD1640  [2]
 LDCM0443  CL52 HEK-293T C807(1.01)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C539(0.98)  LDD1648  [2]
 LDCM0449  CL58 HEK-293T C539(1.29)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C539(1.07)  LDD1654  [2]
 LDCM0456  CL64 HEK-293T C807(0.76)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C539(1.10)  LDD1661  [2]
 LDCM0463  CL70 HEK-293T C539(1.20)  LDD1666  [2]
 LDCM0469  CL76 HEK-293T C807(0.87)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C539(1.04)  LDD1674  [2]
 LDCM0476  CL82 HEK-293T C539(1.18)  LDD1679  [2]
 LDCM0482  CL88 HEK-293T C807(1.13)  LDD1685  [2]
 LDCM0485  CL90 HEK-293T C539(0.86)  LDD1688  [2]
 LDCM0489  CL94 HEK-293T C539(1.10)  LDD1692  [2]
 LDCM0022  KB02 A2058 C539(1.25)  LDD2253  [1]
 LDCM0023  KB03 A2058 C539(1.49)  LDD2670  [1]
 LDCM0024  KB05 MEL167 C539(1.54)  LDD3316  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402