Details of the Target

General Information of Target

Target ID LDTP17041
Target Name Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP)
Gene Name PTPRCAP
Gene ID 5790
Synonyms
LPAP; Protein tyrosine phosphatase receptor type C-associated protein; PTPRC-associated protein; CD45-associated protein; CD45-AP; Lymphocyte phosphatase-associated phosphoprotein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTFKEGLTFKDVAVVFTEEELGLLDPVQRNLYQDVMLENFRNLLSVGHHPFKHDVFLLE
KEKKLDIMKTATQRKGKSADKIQSEVETVPEAGRHEELYWGQIWKQIASDLIKYEDSMIS
ISRFPRQGDLSCQVRAGLYTTHTGQKFYQCDEYKKSFTDVFNFDLHQQLHSGEKSHTCDE
CGKSFCYISALHIHQRVHMGEKCYKCDVCGKEFSQSSHLQTHQRVHTVEKPFKCVECGKG
FSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTGEKPFKCDTCGKNFRRR
SALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECGKCFIQPSQFQ
AHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFRMKIHYQVHLV
VHTGEKPYKCEVCGKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTG
EKPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPF
KCEECGKSFSRSAHLQAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGE
CGKHFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKR
FSWRSNLVSHHKIHAAGTFYENDENSKNIRELSEGGSSTR
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q14761
Ensemble ID
ENST00000326294.4
HGNC ID
HGNC:9667
ChEMBL ID
CHEMBL4806

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y64(19.30)  LDD0260  [1]
IA-alkyne
 Probe Info  		C134(10.00)  LDD2157  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C134(1.49)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C134(0.44)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C134(3.24)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C134(0.38)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C134(0.58)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C134(0.51)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C134(0.27)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C134(0.57)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C134(1.95)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C134(0.65)  LDD2197  [4]
 LDCM0588  Fragment30 Ramos C134(0.73)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C134(0.30)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C134(0.51)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C134(0.53)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C134(0.54)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C134(1.17)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C134(0.71)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C134(1.03)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C134(0.97)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C134(0.45)  LDD2188  [4]
 LDCM0022  KB02 Ramos C134(0.87)  LDD2182  [4]
 LDCM0023  KB03 Ramos C134(0.49)  LDD2183  [4]
 LDCM0024  KB05 Ramos C134(0.51)  LDD2185  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578