Details of the Target

General Information of Target

Target ID LDTP17040
Target Name Zinc finger protein 234 (ZNF234)
Gene Name ZNF234
Gene ID 10780
Synonyms
ZNF269; Zinc finger protein 234; Zinc finger protein 269; Zinc finger protein HZF4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLLTFRDVAVEFSLEEWEHLEPAQKNLYQDVMLENYRNLVSLGLVVSKPDLITFLEQRK
EPWNVKSEETVAIQPDVFSHYNKDLLTEHCTEASFQKVISRRHGSCDLENLHLRKRWKRE
ECEGHNGCYDEKTFKYDQFDESSVESLFHQQILSSCAKSYNFDQYRKVFTHSSLLNQQEE
IDIWGKHHIYDKTSVLFRQVSTLNSYRNVFIGEKNYHCNNSEKTLNQSSSPKNHQENYFL
EKQYKCKEFEEVFLQSMHGQEKQEQSYKCNKCVEVCTQSLKHIQHQTIHIRENSYSYNKY
DKDLSQSSNLRKQIIHNEEKPYKCEKCGDSLNHSLHLTQHQIIPTEEKPCKWKECGKVFN
LNCSLYLTKQQQIDTGENLYKCKACSKSFTRSSNLIVHQRIHTGEKPYKCKECGKAFRCS
SYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQHQTTHTGEKLYKCKVCSKSYARSSNLI
MHQRVHTGEKPYKCKECGKVFSRSSCLTQHRKIHTGENLYKCKVCAKPFTCFSNLIVHER
IHTGEKPYKCKECGKAFPYSSHLIRHHRIHTGEKPYKCKACSKSFSDSSGLTVHRRTHTG
EKPYTCKECGKAFSYSSDVIQHRRIHTGQRPYKCEECGKAFNYRSYLTTHQRSHTGERPY
KCEECGKAFNSRSYLTTHRRRHTGERPYKCDECGKAFSYRSYLTTHRRSHSGERPYKCEE
CGKAFNSRSYLIAHQRSHTREKL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q14588
Ensemble ID
ENST00000426739.7
HGNC ID
HGNC:13027

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C327(0.80)  LDD1514  [1]
IA-alkyne
 Probe Info  		C502(0.00); C822(0.00); C1867(0.00); C907(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C327(0.79)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C327(0.77)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C327(0.66)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C327(0.75)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C327(0.82)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C327(0.69)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C327(0.71)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C327(0.80)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C327(0.91)  LDD1594  [1]
 LDCM0412  CL24 HEK-293T C327(0.94)  LDD1616  [1]
 LDCM0425  CL36 HEK-293T C327(0.75)  LDD1629  [1]
 LDCM0438  CL48 HEK-293T C327(0.87)  LDD1642  [1]
 LDCM0452  CL60 HEK-293T C327(0.87)  LDD1655  [1]
 LDCM0465  CL72 HEK-293T C327(0.83)  LDD1668  [1]
 LDCM0478  CL84 HEK-293T C327(0.81)  LDD1681  [1]
 LDCM0491  CL96 HEK-293T C327(0.82)  LDD1694  [1]
 LDCM0022  KB02 A375.S2 C251(1.19)  LDD2256  [3]
 LDCM0023  KB03 A101D C251(1.20)  LDD2667  [3]
 LDCM0024  KB05 A101D C251(0.93)  LDD3084  [3]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840