Details of the Target

General Information of Target

Target ID LDTP16938
Target Name Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (GATD3)
Gene Name GATD3
Gene ID 8209
Synonyms
C21orf33; GATD3A; Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLGLLCCGAFSLLWAGPVNAGVTQTPKFRVLKTGQSMTLLCAQDMNHEYMYWYRQDPGM
GLRLIHYSVGEGTTAKGEVPDGYNVSRLKKQNFLLGLESAAPSQTSVYFCASSY
Target Bioclass
Other
Family
GATD3 family
Subcellular location
Mitochondrion
Uniprot ID
P0DPI2
Ensemble ID
ENST00000291577.11
HGNC ID
HGNC:1273
ChEMBL ID
CHEMBL5169114

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 3
 Probe Info  		7.75  LDD0381  [1]
D3
 Probe Info  		14.48  LDD0325  [2]
IPM
 Probe Info  		C177(0.00); C176(0.00)  LDD0241  [3]
HHS-475
 Probe Info  		Y206(1.04); Y250(1.10)  LDD0264  [4]
ATP probe
 Probe Info  		K233(0.00); K235(0.00); K223(0.00)  LDD0199  [5]
NAIA_5
 Probe Info  		C153(0.00); C176(0.00); C177(0.00); C244(0.00)  LDD2224  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [7]
HHS-465
 Probe Info  		K141(0.00); Y250(0.00)  LDD2240  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C176(20.00); C244(1.89); C153(0.76); C176(0.75)  LDD2227  [6]
 LDCM0116  HHS-0101 DM93 Y206(1.04); Y250(1.10)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y206(0.93); Y250(1.18)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y250(0.74); Y206(0.89)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y250(1.24); Y206(2.09)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y250(1.35); Y206(3.46)  LDD0268  [4]

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010