Details of the Target

General Information of Target

Target ID LDTP16814
Target Name Melanoma-associated antigen C1 (MAGEC1)
Gene Name MAGEC1
Gene ID 9947
Synonyms
Melanoma-associated antigen C1; Cancer/testis antigen 7.1; CT7.1; MAGE-C1 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAV
GALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQ
KVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETAS
NCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRD
PAYELLITGGTYA
Target Type
Clinical trial
Target Bioclass
Other
TTD ID
T74381
Uniprot ID
O60732
DrugMap ID
TT9M6NA
Ensemble ID
ENST00000285879.5
HGNC ID
HGNC:6812

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E1078Q .
A498 SNV: p.V912M .
CAMA1 SNV: p.E700Q .
CCK81 SNV: p.R1074K .
COLO679 SNV: p.E1051K .
COLO792 SNV: p.P369S .
D283MED SNV: p.H795P .
IGROV1 SNV: p.Q496H .
Ishikawa (Heraklio) 02 ER Deletion: p.E686RfsTer59 .
JURKAT SNV: p.S398R .
JVM3 SNV: p.S750Y .
LNCaP clone FGC SNV: p.P549H .
MCC13 SNV: p.D5N .
MCC26 SNV: p.R954G .
MDAMB157 SNV: p.R954H .
MEWO SNV: p.Q32Ter; p.I213M; p.S240F; p.D1109V .
NCIH1793 SNV: p.D990N .
NCIH1975 SNV: p.Q712H .
NCIH23 SNV: p.L891Ter .
RKO SNV: p.P561L .
SKMEL28 SNV: p.S147F .
SKMEL5 SNV: p.E61K .
TE11 SNV: p.R1029S .
ZR751 SNV: p.D123E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1066(1.00)  LDD3351  [1]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		19.69  LDD0472  [2]
FFF probe3
 Probe Info  		20.00  LDD0465  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H146 C1066(1.44)  LDD2510  [1]
 LDCM0023  KB03 NCI-H146 C1066(1.12)  LDD2927  [1]
 LDCM0024  KB05 NCI-H196 C1066(1.00)  LDD3351  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cv-9201 Vaccine D02DVK

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.