General Information of Target

Target ID LDTP16582
Target Name Putative phosphatidylinositol 4-kinase alpha-like protein P2 (PI4KAP2)
Gene Name PI4KAP2
Synonyms
Putative phosphatidylinositol 4-kinase alpha-like protein P2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDDEEETTASTLRGKPRPPPVSAQSAFSYIPPRRLDPKEHSYYYRPARTGIISLYDCIF
KRRLDYDQKLHRDDREHAKSLGLHVNEEEQERPVGVLTSSVYGKRINQPIEPLNRDFGRA
NHVQADFYRKNDIPSLKEPGFGHIAPS
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family, Type III PI4K subfamily
Uniprot ID
A4QPH2
HGNC ID
HGNC:33577
ChEMBL ID
CHEMBL4105789

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C833(4.48)  LDD3319  [1]
IA-alkyne
 Probe Info 
C571(3.21)  LDD0371  [2]
CY4
 Probe Info 
N.A.  LDD0247  [3]
NAIA_5
 Probe Info 
N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C571(3.21)  LDD0371  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C571(3.46)  LDD0372  [2]
 LDCM0022  KB02 697 C833(2.32)  LDD2245  [1]
 LDCM0023  KB03 697 C833(5.17)  LDD2662  [1]
 LDCM0024  KB05 MEWO C833(4.48)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264