General Information of Target

Target ID LDTP16277
Target Name ER membrane protein complex subunit 9 (EMC9)
Gene Name EMC9
Gene ID 51016
Synonyms
C14orf122; FAM158A; ER membrane protein complex subunit 9; Protein FAM158A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPTEVPQSHPGPSALLLLQLLLPPTSAFFPNIWSLLAAPGSITHQDLTEEAALNVTLQL
FLEQPPPGRPPLRLEDFLGRTLLADDLFAAYFGPGSSRRFRAALGEVSRANAAQDFLPTS
RNDPDLHFDAERLGQGRARLVGALRETVVAARALDHTLARQRLGAALHALQDFYSHSNWV
ELGEQQPHPHLLWPRQELQNLAQVADPTCSDCEELSCPRNWLGFTLLTSGYFGTHPPKPP
GKCSHGGHFDRSSSQPPRGGINKDSTSPGFSPHHMLHLQAAKLALLASIQAFSLLRSRLG
DRDFSRLLDITPASSLSFVLDTTGSMGEEINAAKIQARHLVEQRRGSPMEPVHYVLVPFH
DPGFGPVFTTSDPDSFWQQLNEIHALGGGDEPEMCLSALQLALLHTPPLSDIFVFTDASP
KDAFLTNQVESLTQERRCRVTFLVTEDTSRVQGRARREILSPLRFEPYKAVALASGGEVI
FTKDQHIRDVAAIVGESMAALVTLPLDPPVVVPGQPLVFSVDGLLQKITVRIHGDISSFW
IKNPAGVSQGQEEGGGPLGHTRRFGQFWMVTMDDPPQTGTWEIQVTAEDTPGVRVQAQTS
LDFLFHFGIPMEDGPHPGLYPLTQPVAGLQTQLLVEVTGLGSRANPGDPQPHFSHVILRG
VPEGAELGQVPLEPVGPPERGLLAASLSPTLLSTPRPFSLELIGQDAAGRRLHRAAPQPS
TVVPVLLELSGPSGFLAPGSKVPLSLRIASFSGPQDLDLRTFVNPSFSLTSNLSRAHLEL
NESAWGRLWLEVPDSAAPDSVVMVTVTAGGREANPVPPTHAFLRLLVSAPAPQDRHTTPT
GSSDPILTTATPAFSPFTLVTQGRAGAGLAAGSPWWGTVGGVLLLLGLASW
Target Bioclass
Transporter and channel
Family
EMC8/EMC9 family
Subcellular location
Endoplasmic reticulum membrane
Function
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Uniprot ID
Q9Y3B6
Ensemble ID
ENST00000216799.9
HGNC ID
HGNC:20273

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C177(0.80)  LDD3311  [1]
Acrolein
 Probe Info 
N.A.  LDD0217  [2]
NAIA_5
 Probe Info 
N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C177(0.96)  LDD1510  [4]
 LDCM0280  AC20 HEK-293T C177(0.98)  LDD1519  [4]
 LDCM0288  AC28 HEK-293T C177(1.08)  LDD1527  [4]
 LDCM0297  AC36 HEK-293T C177(0.96)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C177(1.00)  LDD1540  [4]
 LDCM0306  AC44 HEK-293T C177(1.02)  LDD1545  [4]
 LDCM0315  AC52 HEK-293T C177(0.99)  LDD1554  [4]
 LDCM0324  AC60 HEK-293T C177(1.05)  LDD1563  [4]
 LDCM0108  Chloroacetamide HeLa C177(0.00); H171(0.00)  LDD0222  [2]
 LDCM0369  CL100 HEK-293T C177(1.05)  LDD1573  [4]
 LDCM0372  CL103 HEK-293T C177(0.92)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C177(0.89)  LDD1577  [4]
 LDCM0376  CL107 HEK-293T C177(0.94)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C177(1.04)  LDD1581  [4]
 LDCM0381  CL111 HEK-293T C177(0.94)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C177(1.16)  LDD1586  [4]
 LDCM0385  CL115 HEK-293T C177(0.96)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C177(0.96)  LDD1590  [4]
 LDCM0389  CL119 HEK-293T C177(1.02)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C177(1.23)  LDD1595  [4]
 LDCM0394  CL123 HEK-293T C177(1.00)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C177(1.09)  LDD1599  [4]
 LDCM0398  CL127 HEK-293T C177(0.92)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C177(0.96)  LDD1603  [4]
 LDCM0402  CL15 HEK-293T C177(0.87)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C177(1.10)  LDD1607  [4]
 LDCM0408  CL20 HEK-293T C177(1.09)  LDD1612  [4]
 LDCM0415  CL27 HEK-293T C177(1.02)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C177(1.03)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C177(0.99)  LDD1622  [4]
 LDCM0421  CL32 HEK-293T C177(1.12)  LDD1625  [4]
 LDCM0428  CL39 HEK-293T C177(0.90)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C177(0.91)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C177(0.89)  LDD1634  [4]
 LDCM0434  CL44 HEK-293T C177(0.99)  LDD1638  [4]
 LDCM0443  CL52 HEK-293T C177(0.93)  LDD1646  [4]
 LDCM0447  CL56 HEK-293T C177(1.20)  LDD1650  [4]
 LDCM0455  CL63 HEK-293T C177(0.97)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C177(0.98)  LDD1659  [4]
 LDCM0460  CL68 HEK-293T C177(1.09)  LDD1663  [4]
 LDCM0469  CL76 HEK-293T C177(1.09)  LDD1672  [4]
 LDCM0473  CL8 HEK-293T C177(0.91)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C177(1.06)  LDD1677  [4]
 LDCM0481  CL87 HEK-293T C177(0.94)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C177(1.11)  LDD1685  [4]
 LDCM0487  CL92 HEK-293T C177(1.08)  LDD1690  [4]
 LDCM0494  CL99 HEK-293T C177(0.96)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C177(1.10)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C177(1.06)  LDD1671  [4]
 LDCM0022  KB02 A2780 C177(1.51)  LDD2254  [1]
 LDCM0023  KB03 A2780 C177(1.69); C15(1.56)  LDD2671  [1]
 LDCM0024  KB05 G361 C177(0.80)  LDD3311  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ER membrane protein complex subunit 2 (EMC2) EMC2 family Q15006

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402