Details of the Target

General Information of Target

Target ID LDTP16266
Target Name Zinc finger protein with KRAB and SCAN domains 5 (ZKSCAN5)
Gene Name ZKSCAN5
Gene ID 23660
Synonyms
KIAA1015; ZFP95; Zinc finger protein with KRAB and SCAN domains 5; Zinc finger protein 95 homolog; Zfp-95
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRH
CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV
LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL
AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ
AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE
NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDR
KQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSE
EQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR
VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD
AMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQ
RSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGG
RSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRS
SSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMP
NLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYR
SSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLR
GWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNW
RTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQ
RLFWHEDSKPGTLV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9Y2L8
Ensemble ID
ENST00000326775.10
HGNC ID
HGNC:12867

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C757(1.26)  LDD3330  [1]
YN-1
 Probe Info  		N.A.  LDD0447  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C610(1.14)  LDD1507  [3]
 LDCM0259  AC14 HEK-293T C76(1.08)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C610(1.10)  LDD1515  [3]
 LDCM0282  AC22 HEK-293T C76(1.02)  LDD1521  [3]
 LDCM0285  AC25 HEK-293T C610(1.11)  LDD1524  [3]
 LDCM0291  AC30 HEK-293T C76(1.02)  LDD1530  [3]
 LDCM0294  AC33 HEK-293T C610(1.31)  LDD1533  [3]
 LDCM0299  AC38 HEK-293T C76(1.19)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C610(1.26)  LDD1542  [3]
 LDCM0308  AC46 HEK-293T C76(1.09)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C610(1.18)  LDD1550  [3]
 LDCM0317  AC54 HEK-293T C76(1.02)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C610(1.30)  LDD1559  [3]
 LDCM0323  AC6 HEK-293T C76(1.15)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C76(1.06)  LDD1565  [3]
 LDCM0356  AKOS034007680 HEK-293T C610(1.13)  LDD1570  [3]
 LDCM0368  CL10 HEK-293T C76(0.96)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C610(0.98)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C610(0.97)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C610(1.08)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C610(1.04)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C610(1.12)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C610(0.91)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C610(0.95)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C610(1.02)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C610(1.15)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C610(1.02)  LDD1592  [3]
 LDCM0391  CL120 HEK-293T C610(1.06)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C610(1.38)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C610(1.16)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C610(1.20)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C610(1.21)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C610(1.14)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C610(1.12)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C610(0.99)  LDD1608  [3]
 LDCM0407  CL2 HEK-293T C610(1.07)  LDD1611  [3]
 LDCM0410  CL22 HEK-293T C76(1.14)  LDD1614  [3]
 LDCM0414  CL26 HEK-293T C610(1.16)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C610(1.06)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C610(1.25)  LDD1621  [3]
 LDCM0423  CL34 HEK-293T C76(1.07)  LDD1627  [3]
 LDCM0429  CL4 HEK-293T C610(1.25)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C610(1.05)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C610(0.95)  LDD1635  [3]
 LDCM0436  CL46 HEK-293T C76(1.03)  LDD1640  [3]
 LDCM0440  CL5 HEK-293T C610(1.51)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C610(0.99)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C610(0.97)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C610(1.04)  LDD1647  [3]
 LDCM0449  CL58 HEK-293T C76(1.00)  LDD1652  [3]
 LDCM0454  CL62 HEK-293T C610(1.00)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C610(0.96)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C610(1.21)  LDD1660  [3]
 LDCM0463  CL70 HEK-293T C76(1.08)  LDD1666  [3]
 LDCM0467  CL74 HEK-293T C610(1.15)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C610(1.29)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C610(1.06)  LDD1673  [3]
 LDCM0476  CL82 HEK-293T C76(1.01)  LDD1679  [3]
 LDCM0480  CL86 HEK-293T C610(1.43)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C610(1.45)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C610(1.70)  LDD1686  [3]
 LDCM0489  CL94 HEK-293T C76(1.08)  LDD1692  [3]
 LDCM0493  CL98 HEK-293T C610(0.86)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C610(1.14)  LDD1631  [3]
 LDCM0022  KB02 697 C757(1.10)  LDD2245  [1]
 LDCM0023  KB03 22RV1 C757(1.31)  LDD2660  [1]
 LDCM0024  KB05 MIA PaCa-2 C757(1.26)  LDD3330  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402