Details of the Target

General Information of Target

Target ID LDTP16168
Target Name BTB/POZ domain-containing protein 7 (BTBD7)
Gene Name BTBD7
Gene ID 55727
Synonyms
KIAA1525; BTB/POZ domain-containing protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDDSLDELVARSPGPDGHPQVGPADPAGDFEESSVGSSGDSGDDSDSEHGDGTDGEDEG
ASEEEDLEDRSGSEDSEDDGETLLEVAGTQGKLEAAGSFNSDDDAESCPICLNAFRDQAV
GTPENCAHYFCLDCIVEWSKNANSCPVDRTLFKCICIRAQFGGKILRKIPVENTKASEEE
EDPTFCEVCGRSDREDRLLLCDGCDAGYHMECLDPPLQEVPVDEWFCPECAAPGVVLAAD
AGPVSEEEVSLLLADVVPTTSRLRPRAGRTRAIARTRQSERVRATVNRNRISTARRVQHT
PGRLGSSLLDEAIEAVATGLSTAVYQRPLTPRTPARRKRKTRRRKKVPGRKKTPSGPSAK
SKSSATRSKKRQHRVKKRRGKKVKSEATTRSRIARTLGLRRPVHSSCIPSVLKPVEPSLG
LLRADIGAASLSLFGDPYELDPFDSSEELSANPLSPLSAKRRALSRSALQSHQPVARPVS
VGLSRRRLPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVS
FQRNSGSLSRGEEGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPV
RLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLPLASAASKISSRDSKPPCRS
VVPGPPLKPAPRRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGT
GQPGRGTRAESEASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRIN
IPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSPLFSIKKTKQLRSEVYDPSDPTGSDS
SAPGSSPERSGPGLLPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSS
AMSKLRGAVAAEGASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTV
TCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRSTSSSRSRKKAKRKRVSREHGRTRSG
TRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRG
PWGHSRRTSRSRSGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRE
RSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSREKWPQTRSHSPERKGAVRE
ASPAPLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLD
YGDSVEAGHVFDDFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQ
REVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSPDVAPAGKEDSPSASGRVQE
AARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMED
VAPTGVRQVFSELPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQ
FILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNSEEKTPAPRLAAEKTKKEEY
MKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGEINPVKVANLV
KAYVDKYRHMRRHKKPEAGEEPPTQGAEG
Target Bioclass
Other
Subcellular location
Nucleus
Function
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression.
Uniprot ID
Q9P203
Ensemble ID
ENST00000298896.7
HGNC ID
HGNC:18269

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.R936K .
CCK81 SNV: p.R284L .
COLO792 Substitution: p.S31F .
HCT15 SNV: p.E1003G .
HT115 SNV: p.R691Ter .
LNCaP clone FGC Insertion: p.H927TfsTer21 .
LS123 SNV: p.T65A .
MEWO SNV: p.S173F .
NCIH661 SNV: p.R284P .
UACC62 SNV: p.F263V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C141(0.75); C152(0.75)  LDD1164  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0285  AC25 PaTu 8988t C141(0.75); C152(0.75)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C141(0.84); C152(0.84)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C141(0.77); C152(0.77)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C141(0.97); C152(0.97)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C141(1.09); C152(1.09)  LDD1168  [1]
 LDCM0291  AC30 PaTu 8988t C141(0.80); C152(0.80)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C141(0.70); C152(0.70)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C141(0.78); C152(0.78)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C141(0.89); C152(0.89)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C141(0.92); C152(0.92)  LDD1174  [1]
 LDCM0308  AC46 PaTu 8988t C141(1.01); C152(1.01)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C141(0.94); C152(0.94)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C141(1.18); C152(1.18)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C141(1.00); C152(1.00)  LDD1190  [1]
 LDCM0313  AC50 PaTu 8988t C141(0.91); C152(0.91)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C141(1.06); C152(1.06)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C141(0.84); C152(0.84)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C141(0.96); C152(0.96)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C141(1.22); C152(1.22)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C141(0.75); C152(0.75)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C141(0.81); C152(0.81)  LDD1198  [1]
 LDCM0332  AC68 PaTu 8988t C141(1.06); C152(1.06)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C141(1.11); C152(1.11)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C141(1.10); C152(1.10)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C141(1.17); C152(1.17)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C141(1.08); C152(1.08)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C141(0.95); C152(0.95)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C141(1.05); C152(1.05)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C141(1.33); C152(1.33)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C141(1.24); C152(1.24)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C141(0.95); C152(0.95)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C141(1.12); C152(1.12)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C141(1.05); C152(1.05)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C141(0.92); C152(0.92)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C141(1.13); C152(1.13)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C141(1.10); C152(1.10)  LDD1227  [1]
 LDCM0020  ARS-1620 HCC44 C141(1.21); C152(1.21)  LDD2171  [1]
 LDCM0382  CL112 PaTu 8988t C141(0.86); C152(0.86)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C141(0.96); C152(0.96)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C141(0.81); C152(0.81)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C141(0.96); C152(0.96)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C141(0.76); C152(0.76)  LDD1265  [1]
 LDCM0392  CL121 PaTu 8988t C141(0.88); C152(0.88)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C141(0.87); C152(0.87)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C141(1.67); C152(1.67)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C141(1.21); C152(1.21)  LDD1274  [1]
 LDCM0403  CL16 PaTu 8988t C141(1.51); C152(1.51)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C141(1.55); C152(1.55)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C141(0.95); C152(0.95)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C141(1.63); C152(1.63)  LDD1285  [1]
 LDCM0408  CL20 PaTu 8988t C141(1.40); C152(1.40)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C141(1.60); C152(1.60)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C141(1.60); C152(1.60)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C141(1.21); C152(1.21)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C141(1.34); C152(1.34)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C141(1.21); C152(1.21)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C141(1.53); C152(1.53)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C141(1.25); C152(1.25)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C141(1.41); C152(1.41)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C141(1.35); C152(1.35)  LDD1296  [1]
 LDCM0419  CL30 PaTu 8988t C141(1.27); C152(1.27)  LDD1298  [1]
 LDCM0436  CL46 PaTu 8988t C141(1.35); C152(1.35)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C141(1.35); C152(1.35)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C141(1.24); C152(1.24)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C141(0.99); C152(0.99)  LDD1318  [1]
 LDCM0441  CL50 PaTu 8988t C141(1.31); C152(1.31)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C141(1.52); C152(1.52)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C141(1.32); C152(1.32)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C141(1.56); C152(1.56)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C141(1.39); C152(1.39)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C141(1.20); C152(1.20)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C141(0.44); C152(0.44)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C141(1.39); C152(1.39)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C141(1.15); C152(1.15)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C141(1.82); C152(1.82)  LDD1329  [1]
 LDCM0452  CL60 PaTu 8988t C141(1.50); C152(1.50)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C141(0.89); C152(0.89)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C141(1.35); C152(1.35)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C141(0.97); C152(0.97)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C141(1.15); C152(1.15)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C141(1.19); C152(1.19)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C141(1.31); C152(1.31)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C141(1.20); C152(1.20)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C141(1.42); C152(1.42)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C141(0.95); C152(0.95)  LDD1340  [1]
 LDCM0463  CL70 PaTu 8988t C141(1.28); C152(1.28)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C141(0.97); C152(0.97)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C141(1.13); C152(1.13)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C141(1.52); C152(1.52)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C141(1.00); C152(1.00)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C141(1.16); C152(1.16)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C141(1.11); C152(1.11)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C141(1.17); C152(1.17)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C141(0.89); C152(0.89)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C141(1.02); C152(1.02)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C141(1.14); C152(1.14)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C141(1.46); C152(1.46)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C141(1.36); C152(1.36)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C141(1.08); C152(1.08)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C141(0.91); C152(0.91)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C141(1.08); C152(1.08)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C141(1.35); C152(1.35)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C141(1.07); C152(1.07)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C141(1.01); C152(1.01)  LDD1362  [1]
 LDCM0485  CL90 PaTu 8988t C141(1.97); C152(1.97)  LDD1364  [1]
 LDCM0468  Fragment33 PaTu 8988t C141(1.23); C152(1.23)  LDD1347  [1]
 LDCM0021  THZ1 HCT 116 C141(1.21); C152(1.21)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.