Details of the Target

General Information of Target

Target ID LDTP16014
Target Name Serine-rich coiled-coil domain-containing protein 2 (CCSER2)
Gene Name CCSER2
Gene ID 54462
Synonyms
FAM190B; KIAA1128; Serine-rich coiled-coil domain-containing protein 2; Coiled-coil serine-rich protein 2; Protein GCAP14 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESPLIYVSVLLLNIFEFSSGIVYNKDDTEKRFACSNKGFPQENEIIKLYLFLENLKIQC
FFQTENEIASKAMLSVFTSGGLAPSLGIMNSTYNGIFHFNLTLFSDRILWLVDIPRENIT
QSTDIAAVEEWLVRITLHHGLNIYATEGTLLDVIREPILQWTPGDVIPESEISKLYPHVV
DLKVTKCPCANDVALLGFIVDTIVDGVYIGITFGGFWHDYDTTWFNMTQTIYSQLQEEYE
DLSLVDMVLTNHFLVILTSLGLFVSEDLRYPSRHSLSFSRADFCGFERVDYVKGKLWYNE
RCFANREHFEVDYVTVTFERNRTLSESSSCFYSQEPFLEWVPCLPHIFKGIKIFPTVLTF
LVDQERGTGVYLFYNKVRKTAIASVSTLRNNEPNSQSKFPIFRFPSSFSSPVGMVFHPRS
HFLYAYGNQIWLSVDGGNTFQLIANFHDDIIKKTFHSFYTSAITFVSQRGKVYSTKAGMG
RYSAVGSVTERIFTLYYDHLGFLHKLTLGRFEASGPPTAFGNSRNLFGQPPDMGFETALA
PQHTSLDEIIFFAYVPENEPQETIYSKKFGNIHYGKVIHSGKTGRAYIRKVLQHTTPKGF
LSSVIAEMKEPFGLEEVNESSCLSSSLLINKAGNVYKLTLDSQVVQALFEDTDIEKTVVL
PGYSSFLITSILDNKNALAIATMPESAPNNMTFLKSTWFLYNFGQRNGRTWKIYSKPCNY
WFQHDDSPSLNIVKYIDLGNSYVLKAKVIRNAKGFRMLEIPLLTVFVGNPNLLEVTAEVT
FDDTDSYVITISAASKVLHQGSTSLAFIMWSASTECFVTTMVPTLKSSCSYLRSMHHIPS
KFIPFEDWISGVHKDSQGFNLIKTLPINYRPPSNMGIAIPLTDNFYHADPSKPIPRNMFH
MSKKTGKFKQCANVSTREECNCTKDQKFSHAVAFSDCREKVPRFKFPITQYPVSLEIINE
DGRVPLQSPYLVTVTEVNMRHNWKLKHTVPENIKRMKQLVEPILGAAVYNPSGLNLSIKG
SELFHFRVTVISGVTFCNLIEEFQIYVDEAPLPFPGHTLIAVATAVVLGGLIFIAFMFQL
QGIHPWRTFQRWIRRNQEKFSSISLSELIHRSKSEE
Target Bioclass
Other
Family
CCSER family
Subcellular location
Cytoplasm, cytoskeleton
Function Microtubule-binding protein which might play a role in microtubule bundling.
Uniprot ID
Q9H7U1
Ensemble ID
ENST00000224756.12
HGNC ID
HGNC:29197

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C193(1.89)  LDD3374  [1]
IPM
 Probe Info  		C193(2.25)  LDD1701  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C193(0.83)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C193(1.05)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C193(1.03)  LDD1513  [4]
 LDCM0278  AC19 HEK-293T C193(1.07)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C193(1.02)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C193(1.12)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C193(0.88)  LDD1522  [4]
 LDCM0287  AC27 HEK-293T C193(0.93)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C193(1.07)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C193(1.04)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C193(1.10)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C193(1.09)  LDD1531  [4]
 LDCM0296  AC35 HEK-293T C193(0.89)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C193(1.14)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C193(1.02)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C193(0.99)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C193(0.94)  LDD1540  [4]
 LDCM0305  AC43 HEK-293T C193(0.98)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C193(1.02)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C193(1.23)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C193(0.99)  LDD1548  [4]
 LDCM0312  AC5 HEK-293T C193(0.87)  LDD1551  [4]
 LDCM0314  AC51 HEK-293T C193(0.91)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C193(1.03)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C193(1.01)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C193(0.91)  LDD1557  [4]
 LDCM0322  AC59 HEK-293T C193(0.92)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C193(1.15)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C193(1.24)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C193(0.97)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C193(1.03)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C193(1.21)  LDD1511  [4]
 LDCM0379  CL11 HEK-293T C193(0.91)  LDD1583  [4]
 LDCM0406  CL19 HEK-293T C193(0.94)  LDD1610  [4]
 LDCM0408  CL20 HEK-293T C193(1.02)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C193(1.12)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C193(0.94)  LDD1615  [4]
 LDCM0420  CL31 HEK-293T C193(0.68)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C193(1.07)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C193(0.88)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C193(0.98)  LDD1628  [4]
 LDCM0433  CL43 HEK-293T C193(0.76)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C193(0.99)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C193(1.18)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C193(1.17)  LDD1641  [4]
 LDCM0446  CL55 HEK-293T C193(0.94)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C193(1.03)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C193(1.24)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C193(0.95)  LDD1653  [4]
 LDCM0459  CL67 HEK-293T C193(0.88)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C193(1.30)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C193(0.96)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C193(0.87)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C193(0.88)  LDD1667  [4]
 LDCM0472  CL79 HEK-293T C193(0.76)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C193(1.12)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C193(1.04)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C193(0.97)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C193(0.96)  LDD1680  [4]
 LDCM0484  CL9 HEK-293T C193(0.80)  LDD1687  [4]
 LDCM0486  CL91 HEK-293T C193(0.93)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C193(0.90)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C193(0.94)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C193(1.29)  LDD1693  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C193(1.09)  LDD1702  [2]
 LDCM0022  KB02 A-172 C193(1.40)  LDD2251  [1]
 LDCM0023  KB03 MDA-MB-231 C193(2.25)  LDD1701  [2]
 LDCM0024  KB05 OCUM-1 C193(1.89)  LDD3374  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402