Details of the Target

General Information of Target

Target ID LDTP15872
Target Name Zinc finger protein 649 (ZNF649)
Gene Name ZNF649
Gene ID 65251
Synonyms
Zinc finger protein 649
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.
Uniprot ID
Q9BS31
Ensemble ID
ENST00000354957.8
HGNC ID
HGNC:25741

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C360(1.87)  LDD3395  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C360(0.89)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C360(0.97)  LDD1523  [2]
 LDCM0289  AC29 HEK-293T C360(0.88)  LDD1528  [2]
 LDCM0293  AC32 HEK-293T C360(1.06)  LDD1532  [2]
 LDCM0298  AC37 HEK-293T C360(0.93)  LDD1537  [2]
 LDCM0302  AC40 HEK-293T C360(1.01)  LDD1541  [2]
 LDCM0307  AC45 HEK-293T C360(0.84)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C360(1.08)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C360(0.75)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C360(0.76)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C360(1.05)  LDD1558  [2]
 LDCM0325  AC61 HEK-293T C360(0.90)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C360(1.06)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C360(0.96)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C360(0.86)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C360(0.93)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C183(0.92)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C183(0.98)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C360(1.06); C180(1.03)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C183(0.91)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C360(1.01); C180(1.13)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C183(1.03)  LDD1582  [2]
 LDCM0381  CL111 HEK-293T C360(1.05); C180(1.05)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C183(0.98)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C360(0.96); C180(0.89)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C183(1.03)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C360(0.99); C180(0.90)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C360(0.86)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C183(0.96)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C360(1.10); C180(0.91)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C183(0.97)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C360(0.99); C180(0.85)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C183(1.07)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C360(0.98); C180(0.82)  LDD1606  [2]
 LDCM0409  CL21 HEK-293T C360(1.23)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C360(0.97)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C183(0.85)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C360(0.99); C180(0.98)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C360(0.92); C180(0.93)  LDD1622  [2]
 LDCM0422  CL33 HEK-293T C360(1.12)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C360(0.83)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C183(0.92)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C360(0.98); C180(0.86)  LDD1632  [2]
 LDCM0435  CL45 HEK-293T C360(1.68)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C360(0.92)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C183(0.80)  LDD1643  [2]
 LDCM0448  CL57 HEK-293T C360(1.54)  LDD1651  [2]
 LDCM0452  CL60 HEK-293T C360(0.98)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C183(0.92)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C360(1.07); C180(0.87)  LDD1658  [2]
 LDCM0461  CL69 HEK-293T C360(1.05)  LDD1664  [2]
 LDCM0465  CL72 HEK-293T C360(0.95)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C183(0.86)  LDD1669  [2]
 LDCM0475  CL81 HEK-293T C360(1.08)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C360(0.88)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C183(0.89)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C360(1.05); C180(0.82)  LDD1684  [2]
 LDCM0484  CL9 HEK-293T C360(1.08)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C360(1.19)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C360(0.88)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C183(0.98)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C360(0.97); C180(0.78)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C360(1.26); C180(0.88)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C360(0.99); C180(0.91)  LDD1671  [2]
 LDCM0022  KB02 A2058 C360(1.40)  LDD2253  [1]
 LDCM0023  KB03 A2058 C360(1.61)  LDD2670  [1]
 LDCM0024  KB05 PC-3 C360(1.87)  LDD3395  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402