Details of the Target

General Information of Target

Target ID LDTP15824
Target Name Ubiquitin-like protein 7 (UBL7)
Gene Name UBL7
Gene ID 84993
Synonyms
BMSCUBP; Ubiquitin-like protein 7; Bone marrow stromal cell ubiquitin-like protein; BMSC-UbP; Ubiquitin-like protein SB132
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE
TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA
RCKHVHAALRFQGALRRNRCAIM
Target Bioclass
Other
Function
Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway.
Uniprot ID
Q96S82
Ensemble ID
ENST00000361351.8
HGNC ID
HGNC:28221

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
DBIA
 Probe Info  		C66(1.57)  LDD0080  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
m-APA
 Probe Info  		H121(0.00); H7(0.00)  LDD2231  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C66(1.03)  LDD1520  [6]
 LDCM0284  AC24 HEK-293T C66(1.10)  LDD1523  [6]
 LDCM0289  AC29 HEK-293T C66(0.97)  LDD1528  [6]
 LDCM0293  AC32 HEK-293T C66(1.12)  LDD1532  [6]
 LDCM0298  AC37 HEK-293T C66(1.10)  LDD1537  [6]
 LDCM0302  AC40 HEK-293T C66(1.33)  LDD1541  [6]
 LDCM0307  AC45 HEK-293T C66(1.06)  LDD1546  [6]
 LDCM0310  AC48 HEK-293T C66(1.20)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C66(1.03)  LDD1551  [6]
 LDCM0316  AC53 HEK-293T C66(1.00)  LDD1555  [6]
 LDCM0319  AC56 HEK-293T C66(1.05)  LDD1558  [6]
 LDCM0325  AC61 HEK-293T C66(0.91)  LDD1564  [6]
 LDCM0328  AC64 HEK-293T C66(1.08)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C66(1.06)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C66(1.13)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C66(1.12)  LDD1514  [6]
 LDCM0390  CL12 HEK-293T C66(1.09)  LDD1594  [6]
 LDCM0409  CL21 HEK-293T C66(1.00)  LDD1613  [6]
 LDCM0412  CL24 HEK-293T C66(1.09)  LDD1616  [6]
 LDCM0422  CL33 HEK-293T C66(0.86)  LDD1626  [6]
 LDCM0425  CL36 HEK-293T C66(1.11)  LDD1629  [6]
 LDCM0435  CL45 HEK-293T C66(0.90)  LDD1639  [6]
 LDCM0438  CL48 HEK-293T C66(1.13)  LDD1642  [6]
 LDCM0448  CL57 HEK-293T C66(1.10)  LDD1651  [6]
 LDCM0452  CL60 HEK-293T C66(1.03)  LDD1655  [6]
 LDCM0461  CL69 HEK-293T C66(0.83)  LDD1664  [6]
 LDCM0465  CL72 HEK-293T C66(1.12)  LDD1668  [6]
 LDCM0475  CL81 HEK-293T C66(0.93)  LDD1678  [6]
 LDCM0478  CL84 HEK-293T C66(1.09)  LDD1681  [6]
 LDCM0484  CL9 HEK-293T C66(0.93)  LDD1687  [6]
 LDCM0488  CL93 HEK-293T C66(1.14)  LDD1691  [6]
 LDCM0491  CL96 HEK-293T C66(1.15)  LDD1694  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0022  KB02 HCT 116 C66(1.57)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C66(2.22)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C66(1.85)  LDD0082  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA excision repair protein ERCC-1 (ERCC1) ERCC1/RAD10/SWI10 family P07992
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prefoldin subunit 3 (VBP1) Prefoldin subunit alpha family P61758

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402