Details of the Target

General Information of Target

Target ID LDTP15776
Target Name Zinc finger and SCAN domain-containing protein 31 (ZSCAN31)
Gene Name ZSCAN31
Gene ID 64288
Synonyms
ZNF310P; ZNF323; Zinc finger and SCAN domain-containing protein 31; Zinc finger protein 323
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAVSCRQGQHTQQGEHTRVAVPHKQGGNIRGPWARGWKSLWTGLGTIRSDLEELWELRG
HHYLHQESLKPAPVLVEKPLPEWPVPQFINLFLPEFPIRPIRGQQQLKILGLVAKGSFGT
VLKVLDCTQKAVFAVKVVPKVKVLQRDTVRQCKEEVSIQRQINHPFVHSLGDSWQGKRHL
FIMCSYCSTDLYSLWSAVGCFPEASIRLFAAELVLVLCYLHDLGIMHRDVKVENILLDER
GHLKLTDFGLSRHVPQGAQAYTICGTLQYMAPEVLSGGPYNHAADWWSLGVLLFSLATGK
FPVAAERDHVAMLASVTHSDSEIPASLNQGLSLLLHELLCQNPLHRLRYLHHFQVHPFFR
GVAFDPELLQKQPVNFVTETQATQPSSAETMPFDDFDCDLESFLLYPIPA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May function as a transcription factor. May be involved in the development of multiple embryonic organs.
Uniprot ID
Q96LW9
Ensemble ID
ENST00000344279.11
HGNC ID
HGNC:14097

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R240M .
DEL SNV: p.I260T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C59(1.28)  LDD3351  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C337(0.98)  LDD1523  [4]
 LDCM0293  AC32 HEK-293T C337(0.92)  LDD1532  [4]
 LDCM0302  AC40 HEK-293T C337(0.80)  LDD1541  [4]
 LDCM0310  AC48 HEK-293T C337(0.67)  LDD1549  [4]
 LDCM0319  AC56 HEK-293T C337(0.87)  LDD1558  [4]
 LDCM0328  AC64 HEK-293T C337(0.83)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C337(0.83)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C337(0.79)  LDD1514  [4]
 LDCM0632  CL-Sc Hep-G2 C337(0.36)  LDD2227  [2]
 LDCM0390  CL12 HEK-293T C337(0.82)  LDD1594  [4]
 LDCM0412  CL24 HEK-293T C337(0.87)  LDD1616  [4]
 LDCM0425  CL36 HEK-293T C337(1.26)  LDD1629  [4]
 LDCM0438  CL48 HEK-293T C337(0.75)  LDD1642  [4]
 LDCM0452  CL60 HEK-293T C337(0.82)  LDD1655  [4]
 LDCM0465  CL72 HEK-293T C337(1.22)  LDD1668  [4]
 LDCM0478  CL84 HEK-293T C337(0.97)  LDD1681  [4]
 LDCM0491  CL96 HEK-293T C337(0.96)  LDD1694  [4]
 LDCM0022  KB02 HEK-293T C337(0.76)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C337(1.01)  LDD1497  [4]
 LDCM0024  KB05 NCI-H196 C59(1.28)  LDD3351  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402