Details of the Target

General Information of Target

Target ID LDTP15740
Target Name GTP-binding protein Di-Ras2 (DIRAS2)
Gene Name DIRAS2
Gene ID 54769
Synonyms
GTP-binding protein Di-Ras2; Distinct subgroup of the Ras family member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGGEAAAAVEELVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGSGR
LDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Di-Ras family
Subcellular location
Cell membrane
Function Displays low GTPase activity and exists predominantly in the GTP-bound form.
Uniprot ID
Q96HU8
Ensemble ID
ENST00000375765.5
HGNC ID
HGNC:19323

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C123(1.41)  LDD3365  [1]
MPP-AC
 Probe Info  		N.A.  LDD0428  [2]
TER-AC
 Probe Info  		N.A.  LDD0426  [2]
TPP-AC
 Probe Info  		N.A.  LDD0427  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C145(0.83)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C145(0.88)  LDD1497  [3]
 LDCM0024  KB05 OVCAR-3 C123(1.41)  LDD3365  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein ripply1 (RIPPLY1) Ripply family Q0D2K3
Protein unc-45 homolog A (UNC45A) . Q9H3U1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402