Details of the Target

General Information of Target

Target ID LDTP15699
Target Name S100P-binding protein (S100PBP)
Gene Name S100PBP
Gene ID 64766
Synonyms
S100PBPR; S100P-binding protein; S100P-binding protein Riken
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSDFSHAFQKELTCVICLNYLVDPVTICCGHSFCRPCLCLSWEEAQSPANCPACREPSP
KMDFKTNILLKNLVTIARKASLWQFLSSEKQICGTHRQTKKMFCDMDKSLLCLLCSNSQE
HGAHKHHPIEEAAEEHREKLLKQMRILWKKIQENQRNLYEEGRTAFLWRGNVVLRAQMIR
NEYRKLHPVLHKEEKQHLERLNKEYQEIFQQLQRSWVKMDQKSKHLKEMYQELMEMCHKP
DVELLQDLGDIVARSESVLLHMPQPVNPELTAGPITGLVYRLNRFRVEISFHFEVTNHNI
RLFEDVRSWMFRRGPLNSDRSDYFAAWGARVFSFGKHYWELDVDNSCDWALGVCNNSWIR
KNSTMVNSEDIFLLLCLKVDNHFNLLTTSPVFPHYIEKPLGRVGVFLDFESGSVSFLNVT
KSSLIWSYPAGSLTFPVRPFFYTGHR
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q96BU1
Ensemble ID
ENST00000373475.10
HGNC ID
HGNC:25768

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GAMG SNV: p.G185C .
MCC13 SNV: p.H244Y DBIA    Probe Info 
SKMEL5 Substitution: p.S167M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C156(1.57)  LDD3332  [2]
ATP probe
 Probe Info  		K277(0.00); K283(0.00)  LDD0199  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C156(0.98)  LDD1507  [5]
 LDCM0259  AC14 HEK-293T C156(1.17)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C194(0.95)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C156(0.78)  LDD1515  [5]
 LDCM0282  AC22 HEK-293T C156(1.11)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C194(0.86)  LDD1522  [5]
 LDCM0285  AC25 HEK-293T C156(0.89)  LDD1524  [5]
 LDCM0291  AC30 HEK-293T C156(1.00)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C194(0.76)  LDD1531  [5]
 LDCM0294  AC33 HEK-293T C156(0.94)  LDD1533  [5]
 LDCM0299  AC38 HEK-293T C156(1.21)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C194(0.85)  LDD1539  [5]
 LDCM0303  AC41 HEK-293T C156(0.98)  LDD1542  [5]
 LDCM0308  AC46 HEK-293T C156(1.14)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C194(1.11)  LDD1548  [5]
 LDCM0311  AC49 HEK-293T C156(0.99)  LDD1550  [5]
 LDCM0317  AC54 HEK-293T C156(1.05)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C194(1.05)  LDD1557  [5]
 LDCM0320  AC57 HEK-293T C156(0.88)  LDD1559  [5]
 LDCM0323  AC6 HEK-293T C156(0.94)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C156(1.00)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C194(1.13)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C194(0.94)  LDD1568  [5]
 LDCM0356  AKOS034007680 HEK-293T C156(0.92)  LDD1570  [5]
 LDCM0156  Aniline NCI-H1299 11.80  LDD0403  [1]
 LDCM0368  CL10 HEK-293T C156(0.86)  LDD1572  [5]
 LDCM0371  CL102 HEK-293T C156(0.97)  LDD1575  [5]
 LDCM0375  CL106 HEK-293T C156(1.09)  LDD1579  [5]
 LDCM0379  CL11 HEK-293T C194(1.09)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C156(1.13)  LDD1584  [5]
 LDCM0384  CL114 HEK-293T C156(1.27)  LDD1588  [5]
 LDCM0388  CL118 HEK-293T C156(1.11)  LDD1592  [5]
 LDCM0393  CL122 HEK-293T C156(1.15)  LDD1597  [5]
 LDCM0397  CL126 HEK-293T C156(1.10)  LDD1601  [5]
 LDCM0401  CL14 HEK-293T C156(0.97)  LDD1605  [5]
 LDCM0404  CL17 HEK-293T C156(0.95)  LDD1608  [5]
 LDCM0407  CL2 HEK-293T C156(1.06)  LDD1611  [5]
 LDCM0410  CL22 HEK-293T C156(0.96)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C194(1.28)  LDD1615  [5]
 LDCM0414  CL26 HEK-293T C156(1.05)  LDD1618  [5]
 LDCM0417  CL29 HEK-293T C156(1.20)  LDD1621  [5]
 LDCM0423  CL34 HEK-293T C156(0.99)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C194(1.31)  LDD1628  [5]
 LDCM0431  CL41 HEK-293T C156(1.03)  LDD1635  [5]
 LDCM0436  CL46 HEK-293T C156(0.94)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C194(0.78)  LDD1641  [5]
 LDCM0440  CL5 HEK-293T C156(0.87)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C156(1.08)  LDD1645  [5]
 LDCM0444  CL53 HEK-293T C156(0.76)  LDD1647  [5]
 LDCM0449  CL58 HEK-293T C156(0.96)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C194(1.30)  LDD1653  [5]
 LDCM0454  CL62 HEK-293T C156(1.33)  LDD1657  [5]
 LDCM0457  CL65 HEK-293T C156(0.86)  LDD1660  [5]
 LDCM0463  CL70 HEK-293T C156(0.95)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C194(1.07)  LDD1667  [5]
 LDCM0467  CL74 HEK-293T C156(1.17)  LDD1670  [5]
 LDCM0470  CL77 HEK-293T C156(0.93)  LDD1673  [5]
 LDCM0476  CL82 HEK-293T C156(0.96)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C194(0.85)  LDD1680  [5]
 LDCM0480  CL86 HEK-293T C156(0.97)  LDD1683  [5]
 LDCM0483  CL89 HEK-293T C156(0.91)  LDD1686  [5]
 LDCM0489  CL94 HEK-293T C156(1.07)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C194(1.27)  LDD1693  [5]
 LDCM0493  CL98 HEK-293T C156(0.98)  LDD1696  [5]
 LDCM0427  Fragment51 HEK-293T C156(1.16)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C194(1.20)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C194(0.91)  LDD1497  [5]
 LDCM0024  KB05 MKN45 C156(1.57)  LDD3332  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402