Details of the Target

General Information of Target

Target ID LDTP15674
Target Name Mitochondrial import receptor subunit TOM40B (TOMM40L)
Gene Name TOMM40L
Gene ID 84134
Synonyms
TOMM40B; Mitochondrial import receptor subunit TOM40B; Protein TOMM40-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILLNNSHKLLALYKSLARSIPESLKVYGSVYHINHGNPFNMEVLVDSWPEYQMVIIRPQ
KQEMTDDMDSYTNVYRMFSKEPQKSEEVLKNCEIVNWKQRLQIQGLQESLGEGIRVATFS
KSVKVEHSRALLLVTEDILKLNASSKSKLGSWAETGHPDDEFESETPNFKYAQLDVSYSG
LVNDNWKRGKNERSLHYIKRCIEDLPAACMLGPEGVPVSWVTMDPSCEVGMAYSMEKYRR
TGNMARVMVRYMKYLRQKNIPFYISVLEENEDSRRFVGQFGFFEASCEWHQWTCYPQNLV
PF
Target Bioclass
Other
Family
Tom40 family
Subcellular location
Mitochondrion outer membrane
Function Potential channel-forming protein implicated in import of protein precursors into mitochondria.
Uniprot ID
Q969M1
Ensemble ID
ENST00000367987.1
HGNC ID
HGNC:25756

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SG231 SNV: p.D266N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C270(1.32)  LDD0304  [1]
DBIA
 Probe Info  		C270(3.14)  LDD3312  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C270(0.90)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C270(1.09)  LDD1509  [3]
 LDCM0277  AC18 HEK-293T C270(0.96)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C270(1.00)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C270(0.98)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C270(1.06)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C270(0.98)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C270(1.16)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C270(1.01)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C270(0.99)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C270(1.02)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C270(0.93)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C270(1.07)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C270(0.94)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C270(1.06)  LDD1537  [3]
 LDCM0302  AC40 HEK-293T C270(1.34)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C270(0.97)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C270(1.01)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C270(1.09)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C270(0.75)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C270(1.09)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C270(1.10)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C270(1.01)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C270(1.16)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C270(1.16)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C270(1.04)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C270(0.99)  LDD1561  [3]
 LDCM0325  AC61 HEK-293T C270(1.11)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C270(1.43)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C270(0.94)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C270(1.10)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C270(1.11)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C270(1.10)  LDD1571  [3]
 LDCM0370  CL101 HEK-293T C270(1.04)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C270(1.01)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C270(1.04)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C270(1.15)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C270(1.01)  LDD1591  [3]
 LDCM0390  CL12 HEK-293T C270(1.03)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C270(1.04)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C270(1.13)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C270(1.13)  LDD1604  [3]
 LDCM0405  CL18 HEK-293T C270(1.00)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C270(1.06)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C270(1.29)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C270(1.22)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C270(1.00)  LDD1617  [3]
 LDCM0419  CL30 HEK-293T C270(1.05)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C270(1.05)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C270(1.09)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C270(1.34)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C270(1.15)  LDD1630  [3]
 LDCM0432  CL42 HEK-293T C270(1.36)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C270(1.04)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C270(1.08)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C270(1.18)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C270(0.98)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C270(0.93)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C270(1.09)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C270(1.09)  LDD1651  [3]
 LDCM0451  CL6 HEK-293T C270(1.01)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C270(0.84)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C270(1.13)  LDD1656  [3]
 LDCM0458  CL66 HEK-293T C270(1.06)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C270(1.08)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C270(1.18)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C270(1.12)  LDD1665  [3]
 LDCM0465  CL72 HEK-293T C270(1.41)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C270(0.96)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C270(0.96)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C270(0.99)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C270(1.18)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C270(0.99)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C270(1.30)  LDD1682  [3]
 LDCM0484  CL9 HEK-293T C270(1.17)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C270(0.93)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C270(1.12)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C270(1.06)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C270(0.91)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C270(1.04)  LDD1695  [3]
 LDCM0022  KB02 22RV1 C270(1.36)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C270(1.64)  LDD2660  [2]
 LDCM0024  KB05 HMCB C270(3.14)  LDD3312  [2]
 LDCM0131  RA190 MM1.R C270(1.32)  LDD0304  [1]

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402