Details of the Target

General Information of Target

Target ID LDTP15660
Target Name Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP)
Gene Name PHYHIP
Gene ID 9796
Synonyms
DYRK1AP3; KIAA0273; Phytanoyl-CoA hydroxylase-interacting protein; Phytanoyl-CoA hydroxylase-associated protein 1; PAHX-AP1; PAHXAP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMTKHKKCFIIVGVLITTNIITLIVKLTRDSQSLCPYDWIGFQNKCYYFSKEEGDWNSSK
YNCSTQHADLTIIDNIEEMNFLRRYKCSSDHWIGLKMAKNRTGQWVDGATFTKSFGMRGS
EGCAYLSDDGAATARCYTERKWICRKRIH
Target Bioclass
Other
Family
PHYHIP family
Function Its interaction with PHYH suggests a role in the development of the central system.
Uniprot ID
Q92561
Ensemble ID
ENST00000321613.7
HGNC ID
HGNC:16865

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C261(0.88)  LDD2227  [1]
BTD
 Probe Info  		N.A.  LDD0004  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C261(0.44)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C261(0.61)  LDD2112  [3]
 LDCM0632  CL-Sc Hep-G2 C261(0.88)  LDD2227  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C261(4.22)  LDD2096  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C261(0.28)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C261(0.29)  LDD2106  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C261(0.73)  LDD2108  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C261(0.20)  LDD2110  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C261(5.10)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C261(5.10)  LDD2118  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C261(8.38)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C261(8.00)  LDD2124  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C261(5.07)  LDD2126  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C261(0.99)  LDD2141  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C261(11.08)  LDD2149  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C261(5.01)  LDD2151  [3]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761