Details of the Target

General Information of Target

Target ID LDTP15618
Target Name PDZ domain-containing protein GIPC3 (GIPC3)
Gene Name GIPC3
Gene ID 126326
Synonyms
C19orf64; PDZ domain-containing protein GIPC3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAVVPLNKMTAISPEPQTLASTEQNEVPRVVTSGEQEAILRGNAADAESFRQRFRWFCY
SEVAGPRKALSQLWELCNQWLRPDIHTKEQILELLVFEQFLTILPGEIRIWVKSQHPESS
EEVVTLIEDLTQMLEEKDPVSQDSTVSQEENSKEDKMVTVCPNTESCESITLKDVAVNFS
RGEWKKLEPFQKELYKEVLLENLRNLEFLDFPVSKLELISQLKWVELPWLLEEVSKSSRL
DESALDKIIERCLRDDDHGLMEESQQYCGSSEEDHGNQGNSKGRVAQNKTLGSGSRGKKF
DPDKSPFGHNFKETSDLIKHLRVYLRKKSRRYNESKKPFSFHSDLVLNRKEKTAGEKSRK
SNDGGKVLSHSSALTEHQKRQKIHLGDRSQKCSKCGIIFIRRSTLSRRKTPMCEKCRKDS
CQEAALNKDEGNESGEKTHKCSKCGKAFGYSASLTKHRRIHTGEKPYMCNECGKAFSDSS
SLTPHHRTHSGEKPFKCDDCGKGFTLSAHLIKHQRIHTGEKPYKCKDCGRPFSDSSSLIQ
HQRIHTGEKPYTCSNCGKSFSHSSSLSKHQRIHTGEKPYKCGECGKAFRQNSCLTRHQRI
HTGEKPYLCNDCGMTFSHFTSVIYHQRLHSGEKPYKCNQCEKAFPTHSLLSRHQRIHTGV
KPYKCKECGKSFSQSSSLNEHHRIHTGEKPYECNYCGATFSRSSILVEHLKIHTGRREYE
CNECEKTFKSNSGLIRHRGFHSAE
Target Bioclass
Other
Family
GIPC family
Function Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion.
Uniprot ID
Q8TF64
Ensemble ID
ENST00000644452.3
HGNC ID
HGNC:18183

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C79(1.14)  LDD1508  [1]
5E-2FA
 Probe Info  		H163(0.00); H45(0.00)  LDD2235  [2]
m-APA
 Probe Info  		H84(0.00); H163(0.00); H45(0.00)  LDD2231  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Methacrolein
 Probe Info  		C152(0.00); C168(0.00)  LDD0218  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C79(1.14)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C79(1.26)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C79(0.91)  LDD1518  [1]
 LDCM0284  AC24 HEK-293T C79(0.98)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C79(1.59)  LDD1525  [1]
 LDCM0293  AC32 HEK-293T C79(1.15)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C79(1.64)  LDD1534  [1]
 LDCM0302  AC40 HEK-293T C79(1.09)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C79(0.93)  LDD1543  [1]
 LDCM0310  AC48 HEK-293T C79(1.13)  LDD1549  [1]
 LDCM0313  AC50 HEK-293T C79(0.93)  LDD1552  [1]
 LDCM0319  AC56 HEK-293T C79(1.22)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C79(0.86)  LDD1560  [1]
 LDCM0328  AC64 HEK-293T C79(1.16)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C79(1.13)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C79(1.03)  LDD1514  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0390  CL12 HEK-293T C79(1.56)  LDD1594  [1]
 LDCM0405  CL18 HEK-293T C79(0.87)  LDD1609  [1]
 LDCM0412  CL24 HEK-293T C79(1.21)  LDD1616  [1]
 LDCM0419  CL30 HEK-293T C79(1.40)  LDD1623  [1]
 LDCM0425  CL36 HEK-293T C79(1.00)  LDD1629  [1]
 LDCM0432  CL42 HEK-293T C79(0.91)  LDD1636  [1]
 LDCM0438  CL48 HEK-293T C79(0.95)  LDD1642  [1]
 LDCM0445  CL54 HEK-293T C79(1.06)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C79(0.79)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C79(0.96)  LDD1655  [1]
 LDCM0458  CL66 HEK-293T C79(0.94)  LDD1661  [1]
 LDCM0465  CL72 HEK-293T C79(0.97)  LDD1668  [1]
 LDCM0471  CL78 HEK-293T C79(0.94)  LDD1674  [1]
 LDCM0478  CL84 HEK-293T C79(1.06)  LDD1681  [1]
 LDCM0485  CL90 HEK-293T C79(0.77)  LDD1688  [1]
 LDCM0491  CL96 HEK-293T C79(1.32)  LDD1694  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) . Q9HB19

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.