Details of the Target

General Information of Target

Target ID LDTP15615
Target Name Neutral alpha-glucosidase C (GANC)
Gene Name GANC
Gene ID 2595
Synonyms
Neutral alpha-glucosidase C; EC 3.2.1.20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIAHRDWEGDAWRELLVER
LGMTPAQIQALLRKGEKFGRGVIAGLVDIGETLQCPEDLTPDEVVELENQAVLTNLKQKY
LTVISNPRWLLEPIPRKGGKDVFQVDIPEHLIPLGHEV
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 31 family
Function Has alpha-glucosidase activity.
Uniprot ID
Q8TET4
Ensemble ID
ENST00000318010.13
HGNC ID
HGNC:4139
ChEMBL ID
CHEMBL2520

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C114(1.07)  LDD3312  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C114(0.96)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C114(0.91)  LDD1523  [2]
 LDCM0289  AC29 HEK-293T C114(0.93)  LDD1528  [2]
 LDCM0293  AC32 HEK-293T C114(0.98)  LDD1532  [2]
 LDCM0298  AC37 HEK-293T C114(1.00)  LDD1537  [2]
 LDCM0302  AC40 HEK-293T C114(1.08)  LDD1541  [2]
 LDCM0307  AC45 HEK-293T C114(1.04)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C114(0.89)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C114(0.90)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C114(1.10)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C114(1.05)  LDD1558  [2]
 LDCM0325  AC61 HEK-293T C114(1.02)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C114(0.94)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C114(0.98)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C114(1.09)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C114(1.12)  LDD1514  [2]
 LDCM0390  CL12 HEK-293T C114(1.10)  LDD1594  [2]
 LDCM0409  CL21 HEK-293T C114(0.92)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C114(1.21)  LDD1616  [2]
 LDCM0422  CL33 HEK-293T C114(1.00)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C114(1.12)  LDD1629  [2]
 LDCM0435  CL45 HEK-293T C114(0.96)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C114(1.13)  LDD1642  [2]
 LDCM0448  CL57 HEK-293T C114(1.03)  LDD1651  [2]
 LDCM0452  CL60 HEK-293T C114(1.10)  LDD1655  [2]
 LDCM0461  CL69 HEK-293T C114(1.15)  LDD1664  [2]
 LDCM0465  CL72 HEK-293T C114(1.00)  LDD1668  [2]
 LDCM0475  CL81 HEK-293T C114(1.22)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C114(0.91)  LDD1681  [2]
 LDCM0484  CL9 HEK-293T C114(0.97)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C114(1.02)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C114(1.09)  LDD1694  [2]
 LDCM0022  KB02 786-O C114(1.65)  LDD2247  [1]
 LDCM0023  KB03 42-MG-BA C114(1.23)  LDD2661  [1]
 LDCM0024  KB05 HMCB C114(1.07)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402