Details of the Target

General Information of Target

Target ID LDTP15578
Target Name Zinc finger protein 420 (ZNF420)
Gene Name ZNF420
Gene ID 147923
Synonyms
Zinc finger protein 420
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVFLKFFCMSFFCHLCQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSD
HRRCSQGEGSQVGSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLR
RESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDIS
VGLRDKYELLALTIRSHGTRLGRLKNDYLKV
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8TAQ5
Ensemble ID
ENST00000304239.11
HGNC ID
HGNC:20649

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K277T .
CAL72 SNV: p.Q660H .
CCK81 SNV: p.T582S .
HT115 SNV: p.I317M .
KATOIII SNV: p.Q514H .
KYSE510 SNV: p.E18K .
MCC26 SNV: p.I373F; p.L602F .
MELJUSO SNV: p.Q657Ter .
MEWO SNV: p.K450Ter .
MKN1 SNV: p.G359S .
SKMEL5 SNV: p.H129Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C318(1.07)  LDD1508  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]
HHS-465
 Probe Info  		K221(0.00); K224(0.00); Y223(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C318(1.07)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C318(0.88)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C318(1.07)  LDD1512  [1]
 LDCM0277  AC18 HEK-293T C318(1.03)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C318(1.04)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C318(1.08)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C318(1.01)  LDD1521  [1]
 LDCM0286  AC26 HEK-293T C318(1.04)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C318(0.96)  LDD1527  [1]
 LDCM0291  AC30 HEK-293T C318(0.99)  LDD1530  [1]
 LDCM0295  AC34 HEK-293T C318(0.93)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C318(1.05)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C318(0.97)  LDD1538  [1]
 LDCM0301  AC4 HEK-293T C318(1.06)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C318(1.12)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C318(0.98)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C318(1.13)  LDD1547  [1]
 LDCM0313  AC50 HEK-293T C318(1.09)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C318(0.89)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C318(0.97)  LDD1556  [1]
 LDCM0321  AC58 HEK-293T C318(0.89)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C318(0.97)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C318(1.09)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C318(0.94)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C318(1.82)  LDD1572  [1]
 LDCM0405  CL18 HEK-293T C318(1.00)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C318(0.87)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C318(1.14)  LDD1614  [1]
 LDCM0419  CL30 HEK-293T C318(0.95)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C318(0.87)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C318(1.16)  LDD1627  [1]
 LDCM0432  CL42 HEK-293T C318(0.85)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C318(0.97)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C318(1.07)  LDD1640  [1]
 LDCM0445  CL54 HEK-293T C318(1.03)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C318(1.48)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C318(1.17)  LDD1652  [1]
 LDCM0451  CL6 HEK-293T C318(1.15)  LDD1654  [1]
 LDCM0458  CL66 HEK-293T C318(1.17)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C318(1.03)  LDD1663  [1]
 LDCM0463  CL70 HEK-293T C318(1.20)  LDD1666  [1]
 LDCM0471  CL78 HEK-293T C318(1.07)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C318(1.03)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C318(0.89)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C318(0.91)  LDD1679  [1]
 LDCM0485  CL90 HEK-293T C318(1.16)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C318(0.93)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C318(1.15)  LDD1692  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Tumor suppressor ARF (CDKN2A) . Q8N726

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010