Details of the Target

General Information of Target

Target ID LDTP15316
Target Name Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)
Gene Name PPP1R3B
Gene ID 79660
Synonyms
PPP1R4; Protein phosphatase 1 regulatory subunit 3B; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSNAMYNKMWHQTQEALGALLDKEPQKMIEPQRNQVFIFQTLATFYVKYVQIFRNLENVY
DQFVHPQKRILIRKVLDGVMGRILELKNEMVELELTEFHYFDDILQDLKLAPQQLDIPIP
KYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIPFDEAVKLIQIAERARQGRLR
ALFMKQIYLQEYRAKQSKMLGKKVTDTWAAALRIQKVWRRFHQRKETEKLREEEMIFLGM
NPPPLFNEVSATVIQAEKVDRLRNEVQIKHEEDYREALVTIKNDLKLIEGVDIKENLQDQ
IRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDKTIQQVIEDIIANQEEEEKNKKKKKKKE
KQPKKAKKQKKGTKEKNKEEDEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYD
PELIKEEKRKELQSEIRIQVDELMRQELKNLKLAVDRERERPVKAGKKKDKKGKKGKKKE
KKAKKDKDLTADRTIESLYKELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMPS
LLDVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLS
SSNIAGKYPGKNGLQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKK
HLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIER
NGGVLTSALNVSCLAKVTDGFTQGHIVEVVKGVLTDQRIRRQIHKPLTAVEFITAITSMN
PVYKEEEESFKNWYAKTPLGKKRALAITGGSTEKAKDKGKRK
Target Bioclass
Other
Function
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
Uniprot ID
Q86XI6
Ensemble ID
ENST00000310455.4
HGNC ID
HGNC:14942

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C264(0.86)  LDD0812  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C264(0.86)  LDD0812  [1]
 LDCM0216  AC100 HEK-293T C264(0.82)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C264(0.88)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C264(0.77)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C264(0.95)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C264(0.81)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C264(0.91)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C264(1.70)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C264(0.85)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C264(1.21)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C264(1.27)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C264(1.22)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C264(1.32)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C264(0.99)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C264(0.88)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C264(0.69)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C264(0.79)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C264(0.67)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C264(0.60)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C264(0.56)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C264(0.56)  LDD0834  [1]
 LDCM0238  AC120 HEK-293T C264(0.60)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C264(0.64)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C264(0.72)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C264(0.63)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C264(0.63)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C264(0.71)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C264(0.86)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C264(0.88)  LDD0843  [1]
 LDCM0263  AC143 HEK-293T C264(0.77)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C264(1.00)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C264(0.97)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C264(1.00)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C264(1.10)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C264(0.90)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C264(0.84)  LDD0867  [1]
 LDCM0271  AC150 HEK-293T C264(0.96)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C264(0.88)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C264(0.86)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C264(0.95)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C264(0.94)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C264(0.88)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C264(1.03)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C264(1.52)  LDD2165  [1]
 LDCM0279  AC2 HEK-293T C264(0.78)  LDD0877  [1]
 LDCM0285  AC25 HEK-293T C264(0.78)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C264(0.61)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C264(0.67)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C264(0.81)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C264(0.68)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C264(0.82)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C264(0.56)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C264(0.74)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C264(0.68)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C264(0.64)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C264(0.77)  LDD0893  [1]
 LDCM0301  AC4 HEK-293T C264(0.96)  LDD0899  [1]
 LDCM0312  AC5 HEK-293T C264(0.76)  LDD0910  [1]
 LDCM0349  AC83 HEK-293T C264(0.58)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C264(0.41)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C264(0.32)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C264(0.35)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C264(0.47)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C264(0.35)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C264(0.44)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C264(0.57)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C264(0.44)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C264(0.34)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C264(0.40)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C264(0.47)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C264(0.44)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C264(0.31)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C264(0.43)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C264(1.21)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C264(0.73)  LDD0964  [1]
 LDCM0369  CL100 HEK-293T C264(0.67)  LDD0967  [1]
 LDCM0382  CL112 HEK-293T C264(0.69)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C264(0.66)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C264(0.57)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C264(0.75)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C264(0.56)  LDD0984  [1]
 LDCM0453  CL61 HEK-293T C264(0.83)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C264(0.80)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C264(0.82)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C264(0.95)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C264(0.85)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C264(0.84)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C264(1.03)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C264(0.69)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C264(1.02)  LDD1059  [1]
 LDCM0463  CL70 HEK-293T C264(0.97)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C264(0.90)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C264(0.83)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C264(0.71)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C264(0.66)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C264(1.22)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C264(1.51)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C264(2.92)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C264(1.29)  LDD1070  [1]
 LDCM0474  CL80 HEK-293T C264(2.19)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C264(1.56)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C264(1.07)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C264(0.89)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C264(2.00)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C264(1.59)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C264(1.92)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C264(1.06)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C264(1.12)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C264(1.63)  LDD1081  [1]
 LDCM0485  CL90 HEK-293T C264(1.02)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C264(0.73)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C264(0.81)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C264(0.97)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C264(0.74)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C264(0.80)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C264(0.88)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C264(0.98)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C264(0.90)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C264(1.66)  LDD1092  [1]
 LDCM0468  Fragment33 HEK-293T C264(0.58)  LDD1066  [1]
 LDCM0022  KB02 BRX211 C12(2.82)  LDD2268  [2]
 LDCM0023  KB03 BRX211 C12(5.06)  LDD2685  [2]
 LDCM0024  KB05 BRX211 C12(4.56)  LDD3102  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen phosphorylase, brain form (PYGB) Glycogen phosphorylase family P11216
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840