Details of the Target

General Information of Target

Target ID LDTP15262
Target Name Uncharacterized aarF domain-containing protein kinase 2 (ADCK2)
Gene Name ADCK2
Gene ID 90956
Synonyms
AARF; Uncharacterized aarF domain-containing protein kinase 2; EC 2.7.11.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIPMGTQGCFSKSLLLSASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTF
QDFNWYLGEETYGGTRLFTYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTY
QVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLAAGALLISCIAYL
LVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNI
YEVMPSPVLLVSPISDTRSINPARPLPTPPHLQAEPENHQYQQDLLNPDPAPYCQLVPTS
Target Bioclass
Enzyme
Family
Protein kinase superfamily, ADCK protein kinase family
Subcellular location
Membrane
Function
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Involved in the mitochondrial import of CoQ precursors, plays a role in muscle mitochondrial function and fatty acid beta-oxidation.
Uniprot ID
Q7Z695
Ensemble ID
ENST00000072869.9
HGNC ID
HGNC:19039

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(1.12)  LDD3319  [1]
AHL-Pu-1
 Probe Info  		C624(4.09)  LDD0168  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C624(4.09)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C624(4.11)  LDD0169  [2]
 LDCM0270  AC15 HEK-293T C40(0.98)  LDD1513  [5]
 LDCM0283  AC23 HEK-293T C40(1.18)  LDD1522  [5]
 LDCM0292  AC31 HEK-293T C40(0.85)  LDD1531  [5]
 LDCM0300  AC39 HEK-293T C40(0.91)  LDD1539  [5]
 LDCM0309  AC47 HEK-293T C40(1.28)  LDD1548  [5]
 LDCM0318  AC55 HEK-293T C40(1.00)  LDD1557  [5]
 LDCM0327  AC63 HEK-293T C40(1.00)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C40(0.82)  LDD1568  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0372  CL103 HEK-293T C237(1.13)  LDD1576  [5]
 LDCM0376  CL107 HEK-293T C237(1.05)  LDD1580  [5]
 LDCM0379  CL11 HEK-293T C40(0.86)  LDD1583  [5]
 LDCM0381  CL111 HEK-293T C237(1.30)  LDD1585  [5]
 LDCM0385  CL115 HEK-293T C237(0.96)  LDD1589  [5]
 LDCM0389  CL119 HEK-293T C237(1.17)  LDD1593  [5]
 LDCM0394  CL123 HEK-293T C237(1.23)  LDD1598  [5]
 LDCM0398  CL127 HEK-293T C237(1.10)  LDD1602  [5]
 LDCM0402  CL15 HEK-293T C237(1.29)  LDD1606  [5]
 LDCM0411  CL23 HEK-293T C40(0.81)  LDD1615  [5]
 LDCM0415  CL27 HEK-293T C237(0.97)  LDD1619  [5]
 LDCM0418  CL3 HEK-293T C237(1.30)  LDD1622  [5]
 LDCM0424  CL35 HEK-293T C40(1.31)  LDD1628  [5]
 LDCM0428  CL39 HEK-293T C237(1.19)  LDD1632  [5]
 LDCM0437  CL47 HEK-293T C40(1.56)  LDD1641  [5]
 LDCM0450  CL59 HEK-293T C40(0.87)  LDD1653  [5]
 LDCM0455  CL63 HEK-293T C237(1.23)  LDD1658  [5]
 LDCM0464  CL71 HEK-293T C40(0.92)  LDD1667  [5]
 LDCM0477  CL83 HEK-293T C40(1.02)  LDD1680  [5]
 LDCM0481  CL87 HEK-293T C237(0.88)  LDD1684  [5]
 LDCM0490  CL95 HEK-293T C40(1.00)  LDD1693  [5]
 LDCM0494  CL99 HEK-293T C237(1.07)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C237(1.10)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C237(0.89)  LDD1671  [5]
 LDCM0022  KB02 A101D C210(1.19)  LDD2250  [1]
 LDCM0023  KB03 A101D C210(2.07)  LDD2667  [1]
 LDCM0024  KB05 MEWO C210(1.12)  LDD3319  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP/ATP translocase 2 (SLC25A5) Mitochondrial carrier (TC 2.A.29) family P05141

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402