Details of the Target

General Information of Target

Target ID LDTP15023
Target Name Coiled-coil domain-containing protein 181 (CCDC181)
Gene Name CCDC181
Gene ID 57821
Synonyms
C1orf114; Coiled-coil domain-containing protein 181
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDNSAQKNERTGKHPRRASEVQKGFTAAYPTQSSIPFKSQASVIPESEKKGFNSQAKRFP
HKKNDIPGPGFYNVIHQSPVSNSVSLSKKGTCMFPSMCARLDTIISKYPAANAYTIPSDF
ISKRDFSNSCSSMFQLPSFMKALKFETPAPNYYNASVSCCKQRNNVCTRAGFMSKTQRGS
FAFADKGPPPGHYDINESLVKQSPNTLMSCFKSKTNRGLKLTSTGPGPGYYNPSDCTKVP
KKTLFPKNPILNFSAQPSPLPPKPPFPGPGQYEIVDYLGPRKHFISSASFVSNTSRWTAA
PPQPGLPGPATYKPELPGKQSFLYNEDKKWIPVL
Target Bioclass
Other
Family
CCDC181 family
Subcellular location
Cytoplasm, cytoskeleton
Function Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
Uniprot ID
Q5TID7
Ensemble ID
ENST00000367805.7
HGNC ID
HGNC:28051

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 Deletion: p.A454PfsTer6 .
DU145 SNV: p.L23M .
HS936T SNV: p.D156N .
MCC13 Substitution: p.S107F .
MDST8 SNV: p.D146N .
MEWO SNV: p.S192F .
NCIH1993 SNV: p.L388I .
SNGM Insertion: p.S33KfsTer2 .
TE4 SNV: p.D6Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C301(1.27)  LDD1507  [1]
YN-1
 Probe Info  		N.A.  LDD0447  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C301(1.27)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C301(1.17)  LDD1515  [1]
 LDCM0284  AC24 HEK-293T C441(1.03)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C301(1.21)  LDD1524  [1]
 LDCM0293  AC32 HEK-293T C441(0.98)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C301(1.00)  LDD1533  [1]
 LDCM0302  AC40 HEK-293T C441(1.28)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C301(1.14)  LDD1542  [1]
 LDCM0310  AC48 HEK-293T C441(0.96)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C301(1.03)  LDD1550  [1]
 LDCM0319  AC56 HEK-293T C441(1.01)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C301(1.57)  LDD1559  [1]
 LDCM0328  AC64 HEK-293T C441(1.28)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C441(1.02)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C301(1.09)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C441(0.79)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C441(1.51)  LDD1594  [1]
 LDCM0404  CL17 HEK-293T C301(1.63)  LDD1608  [1]
 LDCM0412  CL24 HEK-293T C441(1.49)  LDD1616  [1]
 LDCM0417  CL29 HEK-293T C301(0.89)  LDD1621  [1]
 LDCM0425  CL36 HEK-293T C441(2.49)  LDD1629  [1]
 LDCM0431  CL41 HEK-293T C301(1.34)  LDD1635  [1]
 LDCM0438  CL48 HEK-293T C441(2.03)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C301(1.31)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C301(1.27)  LDD1647  [1]
 LDCM0452  CL60 HEK-293T C441(1.91)  LDD1655  [1]
 LDCM0457  CL65 HEK-293T C301(1.57)  LDD1660  [1]
 LDCM0465  CL72 HEK-293T C441(3.15)  LDD1668  [1]
 LDCM0470  CL77 HEK-293T C301(1.01)  LDD1673  [1]
 LDCM0478  CL84 HEK-293T C441(2.43)  LDD1681  [1]
 LDCM0483  CL89 HEK-293T C301(1.13)  LDD1686  [1]
 LDCM0491  CL96 HEK-293T C441(1.88)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.