Details of the Target

General Information of Target

Target ID LDTP14880
Target Name Kinesin-like protein KIF26B (KIF26B)
Gene Name KIF26B
Gene ID 55083
Synonyms
Kinesin-like protein KIF26B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRRGQRDLWRHNKSCARNRCPRPPRERGGAGFPWVRAQLSVRQFTLRVRVPGPVHLRGR
SPTPALDPLAPLNPLIRGPRTPGLRRWIQSLALLLPNCSSSRIPTVPRPHSGLWVQSDFP
LGFLSRTEPRLTRSCRGAFRSPRPLPKSGQADGTSEESLHLDIQKLKEKRDMLDKEISQF
VSEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKELYPEFGLDMND
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF26 subfamily
Subcellular location
Cytoplasm
Function
Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules.
TTD ID
T74371
Uniprot ID
Q2KJY2
DrugMap ID
TTQWICZ
Ensemble ID
ENST00000407071.7
HGNC ID
HGNC:25484

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.G702A .
A498 SNV: p.G1707W .
AN3CA SNV: p.L1196P .
CCK81 Deletion: p.A1835PfsTer41 .
CHL1 SNV: p.P54L .
DEL SNV: p.K19T .
DU145 SNV: p.S1651N .
EFO27 Deletion: p.A1835PfsTer41 .
ETK1 SNV: p.P331Q .
FADU SNV: p.L2071V .
HCT116 SNV: p.G1417S .
HCT15 SNV: p.A653V .
HEC1 SNV: p.S574Y DBIA    Probe Info 
HEC1B SNV: p.K140R .
HGC27 SNV: p.P1856L .
HUH7 SNV: p.K584Q .
IPC298 SNV: p.S812L .
Ishikawa (Heraklio) 02 ER SNV: p.L11P; p.K753R .
KYSE150 SNV: p.H235N .
LS123 SNV: p.A1714T .
MCC13 SNV: p.G551E; p.E816K .
MCC26 SNV: p.P1106S .
MDAMB468 SNV: p.T347A .
MELHO SNV: p.A1071P .
MEWO SNV: p.G1130E .
MFE280 SNV: p.S679Ter .
MFE296 Deletion: p.A1835PfsTer41 .
MFE319 SNV: p.C541Y DBIA    Probe Info 
NALM6 Deletion: p.R1744EfsTer132 .
NCIH2291 SNV: p.T881S .
NCIH661 SNV: p.Y1851D .
OVCAR8 SNV: p.C571G .
RKO Deletion: p.A1835PfsTer41
SNV: .		 .
RL952 SNV: p.A32T; p.E820K .
SW620 SNV: p.P1484H .
TE1 SNV: p.R1945K .
TE4 SNV: p.S1379C .
TOV21G SNV: p.E1640D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1679(4.08); C1463(2.51); C2013(3.72); C819(2.39)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C671(0.83)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C671(1.03)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C671(1.08)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C671(0.91)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C671(1.01)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C671(0.87)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C671(0.88)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C671(1.33)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C671(1.36)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C671(0.73)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C671(0.76)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C671(1.76)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C671(1.25)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C671(0.81)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C671(0.85)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C671(1.19)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C671(0.79)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C671(0.97)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C671(1.34)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C671(1.15)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C671(0.90)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C671(0.95)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C671(0.92)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C671(1.07)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C671(1.18)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C671(0.99)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C671(0.93)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C671(1.15)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C671(0.81)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C671(1.06)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C671(0.97)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C671(1.26)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C671(0.88)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C671(0.98)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C671(1.10)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C671(1.00)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C671(0.87)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C671(0.83)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C671(0.96)  LDD1568  [2]
 LDCM0356  AKOS034007680 HEK-293T C671(0.85)  LDD1570  [2]
 LDCM0379  CL11 HEK-293T C671(0.94)  LDD1583  [2]
 LDCM0404  CL17 HEK-293T C671(0.95)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C671(1.08)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C671(1.08)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C671(1.07)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C671(1.36)  LDD1615  [2]
 LDCM0417  CL29 HEK-293T C671(0.99)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C671(1.22)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C671(1.23)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C671(1.38)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C671(0.83)  LDD1628  [2]
 LDCM0431  CL41 HEK-293T C671(0.89)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C671(1.20)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C671(1.01)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C671(1.16)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C671(1.02)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C671(1.14)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C671(0.55)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C671(1.16)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C671(1.20)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C671(1.07)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C671(1.21)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C671(1.15)  LDD1654  [2]
 LDCM0457  CL65 HEK-293T C671(0.75)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C671(1.17)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C671(1.12)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C671(2.31)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C671(1.45)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C671(0.95)  LDD1667  [2]
 LDCM0470  CL77 HEK-293T C671(1.30)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C671(1.27)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C671(1.28)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C671(0.81)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C671(1.13)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C671(1.10)  LDD1680  [2]
 LDCM0483  CL89 HEK-293T C671(1.05)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C671(1.05)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C671(1.15)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C671(1.00)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C671(0.85)  LDD1693  [2]
 LDCM0022  KB02 HEK-293T C671(0.91)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C671(0.94)  LDD1497  [2]
 LDCM0024  KB05 NB1 C1679(4.08); C1463(2.51); C2013(3.72); C819(2.39)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402