Details of the Target

General Information of Target

Target ID LDTP14786
Target Name Single-stranded DNA-binding protein 2 (SSBP2)
Gene Name SSBP2
Gene ID 23635
Synonyms
SSDP2; Single-stranded DNA-binding protein 2; Sequence-specific single-stranded-DNA-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL
GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT
GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY
KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM
KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK
HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS
TPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLL
DPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLG
TPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPG
SASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGK
KHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISS
PNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEH
LYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
P81877
Ensemble ID
ENST00000320672.9
HGNC ID
HGNC:15831

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C82(1.69)  LDD3316  [1]
AHL-Pu-1
 Probe Info  		C82(3.33)  LDD0168  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C82(3.33)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C82(3.13)  LDD0169  [2]
 LDCM0632  CL-Sc Hep-G2 C82(0.69)  LDD2227  [8]
 LDCM0372  CL103 HEK-293T C82(1.14)  LDD1576  [9]
 LDCM0376  CL107 HEK-293T C82(1.18)  LDD1580  [9]
 LDCM0381  CL111 HEK-293T C82(1.16)  LDD1585  [9]
 LDCM0385  CL115 HEK-293T C82(1.31)  LDD1589  [9]
 LDCM0389  CL119 HEK-293T C82(1.22)  LDD1593  [9]
 LDCM0394  CL123 HEK-293T C82(1.15)  LDD1598  [9]
 LDCM0398  CL127 HEK-293T C82(1.08)  LDD1602  [9]
 LDCM0402  CL15 HEK-293T C82(1.17)  LDD1606  [9]
 LDCM0415  CL27 HEK-293T C82(1.14)  LDD1619  [9]
 LDCM0418  CL3 HEK-293T C82(1.19)  LDD1622  [9]
 LDCM0428  CL39 HEK-293T C82(1.32)  LDD1632  [9]
 LDCM0455  CL63 HEK-293T C82(1.38)  LDD1658  [9]
 LDCM0481  CL87 HEK-293T C82(1.01)  LDD1684  [9]
 LDCM0494  CL99 HEK-293T C82(1.08)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C82(1.34)  LDD1698  [9]
 LDCM0625  F8 Ramos C82(1.15)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C82(2.47)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C82(0.73)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C82(1.56)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C82(1.03)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C82(0.47)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C82(1.84)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C82(1.46)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C82(1.11)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C82(1.19)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C82(0.44)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C82(1.81)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C82(0.93)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C82(2.32)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C82(1.05)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C82(1.08)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C82(0.73)  LDD2184  [10]
 LDCM0610  Fragment52 Ramos C82(1.47)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C82(1.47)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C82(1.02)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C82(1.57)  LDD2188  [10]
 LDCM0022  KB02 Ramos C82(1.49)  LDD2182  [10]
 LDCM0023  KB03 Ramos C82(0.72)  LDD2183  [10]
 LDCM0024  KB05 MEL167 C82(1.69)  LDD3316  [1]
 LDCM0628  OTUB2-COV-1 HEK-293T C82(0.96)  LDD2207  [11]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.