Details of the Target

General Information of Target

Target ID LDTP14736
Target Name NACHT, LRR and PYD domains-containing protein 11 (NLRP11)
Gene Name NLRP11
Gene ID 204801
Synonyms
NALP11; NOD17; PAN10; PYPAF6; NACHT, LRR and PYD domains-containing protein 11; Nucleotide-binding oligomerization domain protein 17; PAAD-and NACHT domain-containing protein 10; PYRIN-containing APAF1-like protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRIFRPWRLRCPALHLPSLSVFSLRWKLPSLTTDETMCKSVTTDEWKKVFYEKMEEAKPA
DSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQSPYVVILFHMFLDRAQRA
GSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYGERGGQYRIHVASR
QDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKSQDQTGSGWNFCSIP
WCLFWATVLLLIIYLQFSFRSSV
Target Bioclass
Other
Family
NLRP family
Function Involved in inflammation.
Uniprot ID
P59045
Ensemble ID
ENST00000589093.6
HGNC ID
HGNC:22945

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.N817IfsTer7
SNV: p.D5V		 .
COLO792 SNV: p.P1016S .
HCC827 SNV: p.E987G .
HT SNV: p.K27R .
HT115 SNV: p.F104V; p.P999S .
IPC298 SNV: p.R89Q; p.R122C .
KMCH1 SNV: p.L165M .
KO52 SNV: p.Q364H .
LN18 SNV: p.M267I .
MCC13 SNV: p.R122C;p.G158E;p.K223E
Substitution: p.E306K		 .
MCC26 SNV: p.E987K .
MDAMB231 SNV: p.V149L .
MEWO SNV: p.S276F .
MOLT4 SNV: p.H772Y .
NCIH1793 SNV: p.G819V .
NCIH1944 SNV: p.E836D .
NCIH2286 Substitution: p.K355_G356delinsNW .
NCIH661 SNV: p.P467T .
NCIH82 SNV: p.V969L .
RPMI7951 SNV: p.G383R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
aONE
 Probe Info  		N.A.  LDD0002  [1]

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764